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Correspondence
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Volume 330:1830 June 23, 1994 Number 25
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Treatment of Cutaneous T-Cell Lymphoma with Beta Carotene

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To the Editor: Treatment of hematologic cancers has recently focused on the use of tretinoin (retinoic acid), the vitamin A derivative, and similar retinoids to induce differentiation of immature neoplastic cells1. Unfortunately, severe side effects have been documented2. The present report describes the use of beta carotene, a vitamin A precursor, in a patient with chronic lymphocytic leukemia and associated cutaneous T-cell lymphoma. Beta carotene was chosen because it is a remarkably safe substance3.

A 65-year-old man reporting intractable pruritus was examined in April 1993, and scattered erythematous macules were noted. Chronic lymphocytic (T-cell) leukemia had been . . . [Full Text of this Article]

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