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Editorial
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Volume 330:1897-1898 June 30, 1994 Number 26
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Cyclosporine Therapy for Inflammatory Bowel Disease

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Currently, patients with ulcerative colitis or Crohn's disease are treated sequentially with 5-aminosalicylic acid preparations, corticosteroids, and mercaptopurine or azathioprine; metronidazole is beneficial in patients with colonic or perianal Crohn's disease. New systems to deliver 5-aminosalicylic acid are useful in patients with Crohn's disease of the small intestine and eliminate sulfapyridine-associated toxicity, but they are not more effective than sulfasalazine for colonic inflammation. Mercaptopurine and azathioprine are effective in patients with steroid-dependent or unresponsive Crohn's disease, but a three-month delay in response limits their use in acutely ill patients.

The medical community and patients with inflammatory bowel disease have eagerly . . . [Full Text of this Article]

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