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Original Article
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Volume 330:172-177 January 20, 1994 Number 3
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Infection of a Laboratory Worker with Simian Immunodeficiency Virus
Rima F. Khabbaz, Walid Heneine, J. Richard George, Bharat Parekh, Thomas Rowe, Toni Woods, William M. Switzer, Harold M. McClure, Michael Murphey-Corb, and Thomas M. Folks

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Simian immunodeficiency viruses (SIVs) are primate lentiviruses that are morphologically similar and biologically related to human immunodeficiency viruses (HIVs)1,2,3,4. SIVs naturally infect some nonhuman primate species, such as African green monkeys and sooty mangabey monkeys, without causing immunodeficiency. In contrast, experimental SIV infection of other susceptible primate species, such as macaques, can cause chronic wasting syndromes and a disease similar to the human acquired immunodeficiency syndrome (AIDS)5,6,7,8,9,10. Because of the similarities between the human and nonhuman lentiviruses, SIV and its susceptible primate host have become the principal model for studying the pathogenesis of AIDS and developing an HIV . . . [Full Text of this Article]

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From the Retrovirus Diseases Branch, Division of Viral and Rickettsial Diseases (R.F.K., W.H., T.R., T.W., W.M.S., T.M.F.), and the Laboratory Investigations Branch, Division of HIV/AIDS, National Center for Infectious Diseases (J.R.G., B.P.), Centers for Disease Control and Prevention, Atlanta; Yerkes Regional Primate Research Center, Emory University, Atlanta (H.M.M.); and Tulane Regional Primate Center, Tulane University, Covington, La. (M.M.-C.).

Address reprint requests to Dr. Khabbaz at the Centers for Disease Control and Prevention, Mailstop G-03, 1600 Clifton Rd., Atlanta, GA 30333.

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