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Correspondence
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Volume 330:221 January 20, 1994 Number 3
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bcl-2 Protein in Non-Small-Cell Lung Carcinoma

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 by Pezzella, F.
To the Editor: The potential value of the expression of bcl-2 protein as a diagnostic tumor marker and prognostic indicator in non-small-cell lung carcinoma, as described by Pezzella et al. (Sept. 2 issue),1 may be severely limited. The fact that bcl-2 protein was expressed in only 20 percent of their total group of 122 patients and in only 12 percent of patients with adenocarcinoma indicates that this approach is not sensitive enough to be of practical use as a diagnostic screening marker for early lung cancer. Furthermore, the low rate of bcl-2 expression also suggests that this marker is unlikely . . . [Full Text of this Article]

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