Clostridium difficile, the agent that causes pseudomembranouscolitis associated with antibiotic therapy, has been identifiedin recent years as a common nosocomial pathogen. First describedin 1935 by Hall and O'Toole, this gram-positive anaerobic bacilluswas named "the difficult clostridium" because it resisted earlyattempts at isolation and grew very slowly in culture1. Althoughthe organism released potent toxins in broth culture, the factthat it was found in stool specimens from healthy neonates ledto its classification as a commensal. C. difficile subsequentlypassed into obscurity.
In the 1960s and 1970s antibiotic-associated pseudomembranouscolitis became a major clinical . . . [Full Text of this Article]
Pathogenesis
Epidemiology
Clinical Presentation
Laboratory Diagnosis
Treatment
Initial Therapy
Treatment of Recurrent Diarrhea from C. difficile Infection
Source Information
From the Section of Gastroenterology, Evans Memorial Department of Clinical Research, Boston University Medical Center, Boston.
Address reprint requests to Dr. Kelly at Gastroenterology, E201, Boston University Medical Center, University Hospital, 88 E. Newton St., Boston, MA 02118.
References
Related Letters:
Clostridium difficile Colitis
Fang F. C., Madinger N. E., Berman D. S., Wenglin B. D., Goldman W. M., Avicolli A. S., Lutwick S., Kelly C. P., Pothoulakis C., Lamont J. T.
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N Engl J Med 1994;
330:1754-1755, Jun 16, 1994.
Correspondence
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[Abstract][Full Text]
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[Abstract][Full Text]
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[Abstract][Full Text]
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[Abstract][Full Text]
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171: 466-472
[Abstract][Full Text]
Hamilton-Miller, J M T
(2004). Probiotics and prebiotics in the elderly. Postgrad. Med. J.
80: 447-451
[Abstract][Full Text]
Poutanen, S. M., Simor, A. E.
(2004). Clostridium difficile-associated diarrhea in adults. CMAJ
171: 51-58
[Abstract][Full Text]
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(2004). Corticotropin-releasing hormone (CRH) requirement in Clostridium difficile toxin A-mediated intestinal inflammation. Proc. Natl. Acad. Sci. USA
101: 8503-8508
[Abstract][Full Text]
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(2004). Prevalence and Characterization of a Binary Toxin (Actin-Specific ADP-Ribosyltransferase) from Clostridium difficile. J. Clin. Microbiol.
42: 1933-1939
[Abstract][Full Text]
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(2004). Essential Involvement of IFN-{gamma} in Clostridium difficile Toxin A-Induced Enteritis. J. Immunol.
172: 3018-3025
[Abstract][Full Text]
Pfeifer, G., Schirmer, J., Leemhuis, J., Busch, C., Meyer, D. K., Aktories, K., Barth, H.
(2003). Cellular Uptake of Clostridium difficile Toxin B: TRANSLOCATION OF THE N-TERMINAL CATALYTIC DOMAIN INTO THE CYTOSOL OF EUKARYOTIC CELLS. J. Biol. Chem.
278: 44535-44541
[Abstract][Full Text]
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(2003). Reducing delays in the diagnosis and treatment of Clostridium difficile diarrhoea. QJM
96: 579-582
[Abstract][Full Text]
Deng, X. K., Nesbit, L. A., Morrow, K. J. Jr.
(2003). Recombinant Single-Chain Variable Fragment Antibodies Directed against Clostridium difficile Toxin B Produced by Use of an Optimized Phage Display System. CVI
10: 587-595
[Abstract][Full Text]
Ackermann, G., Degner, A., Cohen, S. H., Silva, J. Jr, Rodloff, A. C.
(2003). Prevalence and association of macrolide-lincosamide- streptogramin B (MLSB) resistance with resistance to moxifloxacin in Clostridium difficile. J Antimicrob Chemother
51: 599-603
[Abstract][Full Text]
Belanger, S. D., Boissinot, M., Clairoux, N., Picard, Francois. J., Bergeron, M. G.
(2003). Rapid Detection of Clostridium difficile in Feces by Real-Time PCR. J. Clin. Microbiol.
41: 730-734
[Abstract][Full Text]
Gagan, M. J.
(2003). Review: probiotics are effective in preventing antibiotic associated diarrhoea. Evid. Based Nurs.
6: 16-16
[Full Text]
Dridi, L., Tankovic, J., Burghoffer, B., Barbut, F., Petit, J.-C.
(2002). gyrA and gyrB Mutations Are Implicated in Cross-Resistance to Ciprofloxacin and Moxifloxacin in Clostridium difficile. Antimicrob. Agents Chemother.
46: 3418-3421
[Abstract][Full Text]
Battle, M., Teare, L., Law, S., Fulton, J., Beckly, J., Lewis, S., D'Souza, A L, Rajkumar, C, Cooke, J, Bulpitt, C J
(2002). Probiotics and antibiotic associated diarrhoea. BMJ
325: 901-901
[Full Text]
Calabi, E., Fairweather, N.
(2002). Patterns of Sequence Conservation in the S-Layer Proteins and Related Sequences in Clostridium difficile. J. Bacteriol.
184: 3886-3897
[Abstract][Full Text]
D'Souza, A. L, Rajkumar, C., Cooke, J., Bulpitt, C. J
(2002). Probiotics in prevention of antibiotic associated diarrhoea: meta-analysis. BMJ
324: 1361-1361
[Abstract][Full Text]
Bartlett, J. G.
(2002). Antibiotic-Associated Diarrhea. NEJM
346: 334-339
[Full Text]
Eggimann, P., Pittet, D.
(2001). Infection Control in the ICU. Chest
120: 2059-2093
[Abstract][Full Text]
Gulke, I., Pfeifer, G., Liese, J., Fritz, M., Hofmann, F., Aktories, K., Barth, H.
(2001). Characterization of the Enzymatic Component of the ADP-Ribosyltransferase Toxin CDTa from Clostridium difficile. Infect. Immun.
69: 6004-6011
[Abstract][Full Text]
Afdhal, N. H., Yantiss, R. K.
(2001). Case 25-2001- A 71-Year-Old Man with Gastric Ulcers and Ileocecal Thickening Eight Years after Renal Transplantation. NEJM
345: 526-532
[Full Text]
Kirkwood, K. S., Bunnett, N. W., Maa, J., Castagliolo, I., Liu, B., Gerard, N., Zacks, J., Pothoulakis, C., Grady, E. F.
(2001). Deletion of neutral endopeptidase exacerbates intestinal inflammation induced by Clostridium difficile toxin A. Am. J. Physiol. Gastrointest. Liver Physiol.
281: G544-G551
[Abstract][Full Text]
Kyne, L, Kelly, C P
(2001). Recurrent Clostridium difficile diarrhoea. Gut
49: 152-153
[Full Text]
LaMont, J. T., Graeme-Cook, F. M.
(2001). Case 16-2001- A 17-Year-Old Girl with Worsening Abdominal Pain, Fever, and Diarrhea after a Recent Cesarean Section. NEJM
344: 1622-1627
[Full Text]
Landry, M. L., Topal, J., Ferguson, D., Giudetti, D., Tang, Y.
(2001). Evaluation of Biosite Triage Clostridium difficile Panel for Rapid Detection of Clostridium difficile in Stool Samples. J. Clin. Microbiol.
39: 1855-1858
[Abstract][Full Text]
Qamar, A., Aboudola, S., Warny, M., Michetti, P., Pothoulakis, C., LaMont, J. T., Kelly, C. P.
(2001). Saccharomyces boulardii Stimulates Intestinal Immunoglobulin A Immune Response to Clostridium difficile Toxin A in Mice. Infect. Immun.
69: 2762-2765
[Abstract][Full Text]
Mutlu, G. M., Mutlu, E. A., Factor, P.
(2001). GI Complications in Patients Receiving Mechanical Ventilation. Chest
119: 1222-1241
[Abstract][Full Text]
Mylonakis, E., Ryan, E. T., Calderwood, S. B.
(2001). Clostridium difficile-Associated Diarrhea: A Review. Arch Intern Med
161: 525-533
[Abstract][Full Text]
Kotloff, K. L., Wasserman, S. S., Losonsky, G. A., Thomas, W. Jr., Nichols, R., Edelman, R., Bridwell, M., Monath, T. P.
(2001). Safety and Immunogenicity of Increasing Doses of a Clostridium difficile Toxoid Vaccine Administered to Healthy Adults. Infect. Immun.
69: 988-995
[Abstract][Full Text]
McVay, C. S., Rolfe, R. D.
(2000). In Vitro and In Vivo Activities of Nitazoxanide against Clostridium difficile. Antimicrob. Agents Chemother.
44: 2254-2258
[Abstract][Full Text]
Barbut, F., Richard, A., Hamadi, K., Chomette, V., Burghoffer, B., Petit, J.-C.
(2000). Epidemiology of Recurrences or Reinfections of Clostridium difficile-Associated Diarrhea. J. Clin. Microbiol.
38: 2386-2388
[Abstract][Full Text]
Popoola, J., Swann, A., Warwick, G.
(2000). Clostridium difficile in patients with renal failure -- management of an outbreak using biotherapy. Nephrol Dial Transplant
15: 571-574
[Full Text]
Xia, Y, Hu, H Z, Liu, S, Pothoulakis, C, Wood, J D
(2000). Clostridium difficile toxin A excites enteric neurones and suppresses sympathetic neurotransmission in the guinea pig. Gut
46: 481-486
[Abstract][Full Text]
Genth, H., Selzer, J., Busch, C., Dumbach, J., Hofmann, F., Aktories, K., Just, I.
(2000). New Method To Generate Enzymatically Deficient Clostridium difficile Toxin B as an Antigen for Immunization. Infect. Immun.
68: 1094-1101
[Abstract][Full Text]
Horton, K. M., Corl, F. M., Fishman, E. K.
(2000). CT Evaluation of the Colon: Inflammatory Disease. RadioGraphics
20: 399-418
[Abstract][Full Text]
Stubbe, H., Berdoz, J., Kraehenbuhl, J.-P., Corthesy, B.
(2000). Polymeric IgA Is Superior to Monomeric IgA and IgG Carrying the Same Variable Domain in Preventing Clostridium difficile Toxin A Damaging of T84 Monolayers. J. Immunol.
164: 1952-1960
[Abstract][Full Text]
Kyne, L., Warny, M., Qamar, A., Kelly, C. P.
(2000). Asymptomatic Carriage of Clostridium difficile and Serum Levels of IgG Antibody against Toxin A. NEJM
342: 390-397
[Abstract][Full Text]
Saltzman, J. R., Compton, C. C.
(1999). Case 34-1999- A 37-Year-Old Woman with Liver Disease and Recurrent Diarrhea. NEJM
341: 1530-1537
[Full Text]
Barbut, F., Decré, D., Burghoffer, B., Lesage, D., Delisle, F., Lalande, V., Delmée, M., Avesani, V., Sano, N., Coudert, C., Petit, J.-C.
(1999). Antimicrobial Susceptibilities and Serogroups of Clinical Strains of Clostridium difficile Isolated in France in 1991 and 1997. Antimicrob. Agents Chemother.
43: 2607-2611
[Abstract][Full Text]
Fedorko, D. P., Engler, H. D., O'Shaughnessy, E. M., Williams, E. C., Reichelderfer, C. J., Smith, W. I. Jr.
(1999). Evaluation of Two Rapid Assays for Detection of Clostridium difficile Toxin A in Stool Specimens. J. Clin. Microbiol.
37: 3044-3047
[Abstract][Full Text]
Kovithavongs, T., Cunney, R. J., Magee, C., McNamara, E., Smyth, E. G., Walshe, J.
(1999). Clostridium difficile colitis associated with chronic renal failure. Nephrol Dial Transplant
14: 2256-2257
[Full Text]
Kawamoto, S., Horton, K. M., Fishman, E. K.
(1999). Pseudomembranous Colitis: Spectrum of Imaging Findings with Clinical and Pathologic Correlation. RadioGraphics
19: 887-897
[Abstract][Full Text]
Navarre, W. W., Schneewind, O.
(1999). Surface Proteins of Gram-Positive Bacteria and Mechanisms of Their Targeting to the Cell Wall Envelope. Microbiol. Mol. Biol. Rev.
63: 174-229
[Abstract][Full Text]
Warny, M, Fatimi, A, Bostwick, E F, Laine, D C, Lebel, F, LaMont, J T, Pothoulakis, C, Kelly, C P
(1999). Bovine immunoglobulin concentrate-Clostridium difficile retains C difficile toxin neutralising activity after passage through the human stomach and small intestine. Gut
44: 212-217
[Abstract][Full Text]
Castagliuolo, I., Riegler, M. F., Valenick, L., LaMont, J. T., Pothoulakis, C.
(1999). Saccharomyces boulardii Protease Inhibits the Effects of Clostridium difficile Toxins A and B in Human Colonic Mucosa. Infect. Immun.
67: 302-307
[Abstract][Full Text]
Rocha, M. F. G., Soares, A. M., Flores, C. A., Steiner, T. S., Lyerly, D. M., Guerrant, R. L., Ribeiro, R. A., Lima, A. A. M.
(1998). Intestinal Secretory Factor Released by Macrophages Stimulated with Clostridium difficile Toxin A: Role of Interleukin 1beta. Infect. Immun.
66: 4910-4916
[Abstract][Full Text]
Busch, C., Hofmann, F., Selzer, J., Munro, S., Jeckel, D., Aktories, K.
(1998). A Common Motif of Eukaryotic Glycosyltransferases Is Essential for the Enzyme Activity of Large Clostridial Cytotoxins. J. Biol. Chem.
273: 19566-19572
[Abstract][Full Text]
Ciesla Jr., W. P., Bobak, D. A.
(1998). Clostridium difficile Toxins A and B Are Cation-dependent UDP-glucose Hydrolases with Differing Catalytic Activities. J. Biol. Chem.
273: 16021-16026
[Abstract][Full Text]
Herrmann, C., Ahmadian, M. R., Hofmann, F., Just, I.
(1998). Functional Consequences of Monoglucosylation of Ha-Ras at Effector Domain Amino Acid Threonine 35. J. Biol. Chem.
273: 16134-16139
[Abstract][Full Text]
Shmerling, R. H., Caliendo, A. M.
(1998). Case 19-1998- A 70-Year-Old Man with Diarrhea, Polyarthritis, and a History of Reiter's Syndrome. NEJM
338: 1830-1836
[Full Text]
Castagliuolo, I., Keates, A. C., Wang, C. C., Pasha, A., Valenick, L., Kelly, C. P., Nikulasson, S. T., LaMont, J. T., Pothoulakis, C.
(1998). Clostridium difficile Toxin A Stimulates Macrophage- Inflammatory Protein-2 Production in Rat Intestinal Epithelial Cells. J. Immunol.
160: 6039-6045
[Abstract][Full Text]
Kink, J. A., Williams, J. A.
(1998). Antibodies to Recombinant Clostridium difficile Toxins A and B Are an Effective Treatment and Prevent Relapse of C. difficile-Associated Disease in a Hamster Model of Infection. Infect. Immun.
66: 2018-2025
[Abstract][Full Text]
Pothoulakis, C., Castagliuolo, I., LaMont, J. T.
(1998). Nerves and Intestinal Mast Cells Modulate Responses to Enterotoxins. Physiology
13: 58-63
[Abstract][Full Text]
Hofmann, F., Busch, C., Aktories, K.
(1998). Chimeric Clostridial Cytotoxins: Identification of the N-Terminal Region Involved in Protein Substrate Recognition. Infect. Immun.
66: 1076-1081
[Abstract][Full Text]
Keates, A. C., Castagliuolo, I., Qiu, B., Nikulasson, S., Sengupta, A., Pothoulakis, C.
(1998). CGRP upregulation in dorsal root ganglia and ileal mucosa during Clostridium difficile toxin A-induced enteritis. Am. J. Physiol. Gastrointest. Liver Physiol.
274: G196-G202
[Abstract][Full Text]
Linevsky, J. K., Pothoulakis, C., Keates, S., Warny, M., Keates, A. C., Lamont, J. T., Kelly, C. P.
(1997). IL-8 release and neutrophil activation by Clostridium difficile toxin-exposed human monocytes. Am. J. Physiol. Gastrointest. Liver Physiol.
273: G1333-G1340
[Abstract][Full Text]
Sands, B. E., Compton, C. C.
(1997). Case 36-1997- A 58-Year-Old Man with Recurrent Ulcerative Colitis, Bloody Diarrhea, and Abdominal Distention. NEJM
337: 1532-1540
[Full Text]
Salcedo, J, Keates, S, Pothoulakis, C, Warny, M, Castagliuolo, I, LaMont, J T, Kelly, C P
(1997). Intravenous immunoglobulin therapy for severe Clostridium difficile colitis. Gut
41: 366-370
[Abstract][Full Text]
Castagliuolo, I., Keates, A. C., Qiu, B., Kelly, C. P., Nikulasson, S., Leeman, S. E., Pothoulakis, C.
(1997). Increased substance P responses in dorsal root ganglia and intestinal macrophages during Clostridium difficile toxin A enteritis in rats. Proc. Natl. Acad. Sci. USA
94: 4788-4793
[Abstract][Full Text]
Hofmann, F., Busch, C., Prepens, U., Just, I., Aktories, K.
(1997). Localization of the Glucosyltransferase Activity of Clostridium difficile Toxin B to the N-terminal Part of the Holotoxin. J. Biol. Chem.
272: 11074-11078
[Abstract][Full Text]
Thaler, S. J., Compton, C. C.
(1997). Case 3-1997- A 39-Year-Old Man with Diarrhea and Abdominal Pain after Chemotherapy for Acute Leukemia. NEJM
336: 277-284
[Full Text]
Ives, D. V., Smith, R. N.
(1996). Case 17-1996- A 48-year-old man with the acquired immunodeficiency syndrome, abdominal pain, and bloody diarrhea. NEJM
334: 1461-1468
[Full Text]
Just, I., Wilm, M., Selzer, Jör., Rex, G., Eichel-Streiber, C. v., Mann, M., Aktories, K.
(1995). The Enterotoxin from Clostridium difficile (ToxA) Monoglucosylates the Rho Proteins. J. Biol. Chem.
270: 13932-13936
[Abstract][Full Text]
Fang, F. C., Madinger, N. E., Berman, D. S., Wenglin, B. D., Goldman, W. M., Avicolli, A. S., Lutwick, S., Kelly, C. P., Pothoulakis, C., Lamont, J. T.
(1994). Clostridium difficile Colitis. NEJM
330: 1754-1755
[Full Text]
Barth, H., Pfeifer, G., Hofmann, F., Maier, E., Benz, R., Aktories, K.
(2001). Low pH-induced Formation of Ion Channels by Clostridium difficile Toxin B in Target Cells. J. Biol. Chem.
276: 10670-10676
[Abstract][Full Text]
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