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Previous Volume 330:328-336 February 3, 1994 Number 5 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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Genes involved in the pathogenesis of cancer are thought to act by two general mechanisms. The first involves the structural alteration of a normal gene (a proto-oncogene) to generate a novel gene (an oncogene) whose protein product acts on the host cell to induce characteristics of malignancy. This protein product is usually involved in cellular proliferation, differentiation, or survival. The second mechanism involves the loss or inactivation of genes whose proteins suppress cancer. Genes of this class are known as tumor-suppressor genes or anti-oncogenes.

Alterations in members of specific gene families are consistently associated with some types of leukemia. Table . . . [Full Text of this Article]

Altered Gene Families in Leukemia

Correlation of Specific Genetic Abnormalities with Specific Types of Leukemia

Genetic Abnormalities Common to a Wide Range of Leukemias

ras Genes

Anti-Oncogenes

Immunoglobulin and T-Cell-Receptor Genes in B-Cell and T-Cell Cancers

B Cells

T Cells

Activation of Oncogenes by Novel Fusions of Genes

Molecular Basis of Disease Progression

Summary of Molecular Abnormalities in Leukemia

Acute Myeloid Leukemia

Myelodysplastic Syndromes

Acute Lymphoblastic Leukemia

Chronic Myelocytic Leukemia and Ph¹-Positive Acute Lymphoblastic Leukemia

Chronic Lymphocytic Leukemia

Acute Promyelocytic Leukemia

Molecular Diagnosis and Therapy: Implications for the Clinic

Source Information

From the Division of Hematology, Center for the Health Sciences, 10833 LeConte Ave., Los Angeles, CA 90024-1678, where reprint requests should be addressed to Dr. Cline.

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