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Review Article
Drug Therapy
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Volume 330:484-489 February 17, 1994 Number 7
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The Treatment of Multiple Myeloma
Raymond Alexanian, and Meletios Dimopoulos

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Multiple myeloma accounts for 10 percent of hematologic cancers and kills approximately 10,000 Americans each year. The disease is more common in older persons, and blacks are affected twice as frequently as whites. The cause of multiple myeloma is unknown, and its extent, complications, sensitivity to drugs, and clinical course vary widely among patients. Since many aspects of the biology of this disease have recently been discussed elsewhere,1 this review will focus on treatment.

Solitary Bone Myeloma

Approximately 3 percent of patients have only one bone lesion and no evidence of bone marrow plasmacytosis. Fifty percent of such patients have low concentrations of . . . [Full Text of this Article]

Asymptomatic Multiple Myeloma

Multiple Myeloma

Management of Common Complications

Primary Chemotherapy

Maintenance Treatment

Unresponsive or Relapsing Myeloma

VAD-Resistant Myeloma

Myeloablative Therapies

Conclusions


Source Information

From the University of Texas M.D. Anderson Cancer Center, Houston.

Address reprint requests to Dr. Alexanian at Box 1, 1515 Holcombe Blvd., Houston, TX 77030.

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