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Previous Volume 330:637-639 March 3, 1994 Number 9 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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Molecular investigations of cancer cells have identified genes, proteins, and biochemical pathways that may be useful for diagnosing and classifying cancer, formulating a prognosis, or identifying people who are predisposed to cancer. These studies have revealed two classes of genes related to cancer: proto-oncogenes and tumor-suppressor genes. The latter are now under intense scrutiny; nine tumor-suppressor genes have been identified by molecular cloning techniques (three in the past year¹), and investigations of a variety of cancers suggest the existence of at least two dozen others.

Evidence implicating suppressor genes in the cause of cancer comes mainly from studies of . . . [Full Text of this Article]

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