FREE NEJM E-TOC    HOME   |   SUBSCRIBE   |   CURRENT ISSUE   |   PAST ISSUES   |   COLLECTIONS   |   Search Term  Advanced Search

Sign in | Get NEJM's E-Mail Table of Contents — Free | Subscribe

Previous Volume 331:49-50 July 7, 1994 Number 1 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

	Full Text Purchase this article Letters Add to Personal Archive Add to Citation Manager Notify a Friend E-mail When Cited PubMed Citation

Although gene therapy and immunotherapy hold great promise for the future, cancer treatment now centers around surgical resection, radiation therapy, and chemotherapy. The therapeutic basis of surgical resection is obvious, but the same cannot be said for the other approaches. What accounts for the selective killing of malignant cells while normal cells are spared? It is clearly not simple differences in rates of replication. Why do cancers even of the same histologic type vary in their sensitivity to chemotherapy and radiotherapy? What accounts for the frustrating development of drug resistance? Recent findings provide a possible link between these questions and . . . [Full Text of this Article]

References

Related Letters:

Cancer Therapy Meets p53
Rutz H. P.
Extract | Full Text  
N Engl J Med 1994; 331:1314-1315, Nov 10, 1994. Correspondence

This article has been cited by other articles:

• Cheng, Q., Luo, X., Zhang, B., Jiang, X., Yi, B., Wu, M. (2007). Distal Bile Duct Carcinoma: Prognostic Factors After Curative Surgery. A Series of 112 Cases. Ann. Surg. Oncol. 14: 1212-1219 [Abstract] [Full Text]  
• Licitra, L., Suardi, S., Bossi, P., Locati, L.D., Mariani, L., Quattrone, P., Lo Vullo, S., Oggionni, M., Olmi, P., Cantu, G., Pierotti, M.A., Pilotti, S. (2004). Prediction of TP53 Status for Primary Cisplatin, Fluorouracil, and Leucovorin Chemotherapy in Ethmoid Sinus Intestinal-Type Adenocarcinoma. JCO 22: 4901-4906 [Abstract] [Full Text]  
• Pollack, I. F., Finkelstein, S. D., Woods, J., Burnham, J., Holmes, E. J., Hamilton, R. L., Yates, A. J., Boyett, J. M., Finlay, J. L., Sposto, R., the Children's Cancer Group, (2002). Expression of p53 and Prognosis in Children with Malignant Gliomas. NEJM 346: 420-427 [Abstract] [Full Text]  
• Pollack, I. F., Finkelstein, S. D., Burnham, J., Holmes, E. J., Hamilton, R. L., Yates, A. J., Finlay, J. L., Sposto, R. (2001). Age and TP53 Mutation Frequency in Childhood Malignant Gliomas: Results in a Multi-institutional Cohort. Cancer Res. 61: 7404-7407 [Abstract] [Full Text]  
• Reles, A., Wen, W. H., Schmider, A., Gee, C., Runnebaum, I. B., Kilian, U., Jones, L. A., El-Naggar, A., Minguillon, C., Schonborn, I., Reich, O., Kreienberg, R., Lichtenegger, W., Press, M. F. (2001). Correlation of p53 Mutations with Resistance to Platinum-based Chemotherapy and Shortened Survival in Ovarian Cancer. Clin. Cancer Res. 7: 2984-2997 [Abstract] [Full Text]  
• Achenbach, T. V., Slater, E. P., Brummerhop, H., Bach, T., Müller, R. (2000). Inhibition of Cyclin-Dependent Kinase Activity and Induction of Apoptosis by Preussin in Human Tumor Cells. Antimicrob. Agents Chemother. 44: 2794-2801 [Abstract] [Full Text]  
• Nunn, J., Scholes, A.G.M., Liloglou, T., Nagini, S., Jones, A.S., Vaughan, E.D., Gosney, J.R., Rogers, S., Fear, S., Field, J.K. (1999). Fractional allele loss indicates distinct genetic populations in the development of squamous cell carcinoma of the head and neck (SCCHN). Carcinogenesis 20: 2219-2228 [Abstract] [Full Text]  
• Lee, S. J., Ha, M. J., Lee, J., Nguyen, P., Choi, Y. H., Pirnia, F., Kang, W.-K., Wang, X.-F., Kim, S.-J., Trepel, J. B. (1998). Inhibition of the 3-Hydroxy-3-methylglutaryl-coenzyme A Reductase Pathway Induces p53-independent Transcriptional Regulation of p21WAF1/CIP1 in Human Prostate Carcinoma Cells. J. Biol. Chem. 273: 10618-10623 [Abstract] [Full Text]  
• Elmore, L. W., Hancock, A. R., Chang, S.-F., Wang, X. W., Chang, S., Callahan, C. P., Geller, D. A., Will, H., Harris, C. C. (1997). Hepatitis B virus X protein and p53 tumor suppressor interactions in the modulation of apoptosis. Proc. Natl. Acad. Sci. USA 94: 14707-14712 [Abstract] [Full Text]  
• Rutz, H. P. (1994). Cancer Therapy Meets p53. NEJM 331: 1314-1315 [Full Text]