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Previous Volume 331:59 July 7, 1994 Number 1 Next

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To the Editor: Dunkle et al. (Nov. 28, 1991, issue)¹ reported that treatment with acyclovir reduces the duration and severity of chickenpox in normal children when therapy is begun during the first 24 hours after the appearance of rash. The effect of acyclovir treatment on susceptibility to recurrent or reactivated varicella-zoster virus infection is controversial². In April 1992, the three-year-old daughter of one of us (Patient 1) contracted chickenpox and inadvertently inoculated five children, including her sister (Patient 2) and her best friend (Patient 3). Patient 1 had hundreds of vesicles on her trunk and face and still has . . . [Full Text of this Article]

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