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Previous Volume 331:741-746 September 15, 1994 Number 11 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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To the Editor: Wood et al. (May 5 issue)¹ report the results of a randomized study of different doses and levels of dose intensity (dose per unit of time) of adjuvant chemotherapy in women with stage II, node-positive breast cancer. The study is an excellent example of the merits of the conventional study design, but also of its limitations.

Wood et al. correctly conclude that the toxicity of treatment is directly related to the dose intensity, the dose rate, or both (their Table 1)¹. This means that the toxicity is related to the area under the concentration-time curve after . . . [Full Text of this Article]

References

This article has been cited by other articles:

• Weiss, R. B., Woolf, S. H., Demakos, E., Holland, J. F., Berry, D. A., Falkson, G., Cirrincione, C. T., Robbins, A., Bothun, S., Henderson, I. C., Norton, L. (2003). Natural History of More Than 20 Years of Node-Positive Primary Breast Carcinoma Treated With Cyclophosphamide, Methotrexate, and Fluorouracil-Based Adjuvant Chemotherapy: A Study by the Cancer and Leukemia Group B. JCO 21: 1825-1835 [Abstract] [Full Text]