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Review Article
Drug Therapy
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Volume 331:785-791 September 22, 1994 Number 12
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Risks and Benefits of Antiarrhythmic Therapy
Dan M. Roden

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Drug treatment of cardiac arrhythmias is not uniformly effective and frequently causes side effects. Recently, new data have become available that more clearly delineate the risks of antiarrhythmic-drug therapy. At the same time, establishing a benefit of treatment with these drugs has proved difficult. The potential benefits of antiarrhythmic therapy -- reductions in mortality or in symptoms related to arrhythmias -- as well as the potential risks are outlined in Table 1. In this review I shall consider the available data defining these risks and benefits (which have usually been delineated in specific groups of patients using specific drugs), . . . [Full Text of this Article]

Effects of Antiarrhythmic Therapy on Mortality

Effects of Antiarrhythmic Drugs on Arrhythmia-Related Symptoms

Provocation of Arrhythmias by Antiarrhythmic Drugs

Torsade de Pointes

Incessant Ventricular Tachycardia

Other Risks of Antiarrhythmic-Drug Therapy

An Approach to the Treatment of Arrhythmias

Whom to Treat for Specific Arrhythmias

Minimizing the Risks of Antiarrhythmic Therapy

Future Trends in Antiarrhythmic Therapy


Source Information

From the Division of Clinical Pharmacology, Vanderbilt University, 532C Medical Research Bldg., Nashville, TN 37232-6602, where reprint requests should be addressed to Dr. Roden.

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