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Previous Volume 331:803-804 September 22, 1994 Number 12 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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The major histocompatibility complex (MHC) was discovered and so named because of its association with allograft rejection in animals. Thus, when kidney transplantation in humans became a reality it was not surprising that the degree of matching of organ donors and recipients for the antigens of the human MHC (HLA antigens) strongly predicted the probability of graft acceptance. The initial experience with kidney transplantation, which involved living related donors, demonstrated that the number of shared HLA chromosomal segments (haplotypes) predicted the outcome and the degree of immunosuppressive therapy required. Likewise, in 1966 Terasaki and coworkers reported an association between HLA . . . [Full Text of this Article]

References

This article has been cited by other articles:

• Gaston, R. S., Deierhoi, M. H., Ayres, I., Takemoto, S., Terasaki, P. I., Gjertson, D. W., Cecka, J. M., Held, P. J., Port, F. K., Hunsicker, L. G., Kahan, B. D., Sanfilippo, F. (1995). HLA Matching in Renal Transplantation. NEJM 332: 752-753 [Full Text]