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Correspondence
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Volume 331:814 September 22, 1994 Number 12
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Clinical Problem-Solving: Localizing the Source of Ectopic Corticotropin

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 by Kreisberg, R.
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To the Editor: The differential diagnosis of corticotropin-dependent Cushing's syndrome and the localization of an ectopic source of corticotropin secretion are among the most difficult tasks in endocrinology. In his excellent discussion of the evaluation of an occult corticotropin-secreting tumor (May 5 issue),1 Dr. Kreisberg stops short of suggesting any further workup when conventional radiologic procedures (chest film, computed tomography [CT], and magnetic resonance imaging of both chest and abdomen) fail to detect the tumor.

In a recent series of 10 consecutive patients with ectopic corticotropin secretion, the source of the hormone remained obscure in 5 patients. As early as . . . [Full Text of this Article]

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