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Previous Volume 331:873-874 September 29, 1994 Number 13 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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Crohn's disease and ulcerative colitis are chronic, medically incurable inflammatory bowel diseases. Most patients with these disorders are treated at some point with systemic corticosteroids. The short-term response to corticosteroids may be gratifying, but the long-term effects can be so severe that the treatment is often worse than the disease.

The ideal treatment for inflammatory bowel disease would therefore be a "magic bullet" that could induce clinical remissions as effectively as traditional corticosteroids without having as many side effects. For nearly 40 years, this principle has been used effectively in the topical therapy of distal colitis with hydrocortisone enemas. Many . . . [Full Text of this Article]

References

This article has been cited by other articles:

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• NEURATH, M. F., WANITSCHKE, R., PETERS, M., HILDNER, K., TUFAN, R., ZUM BUSCHENFELDE, K. M., SCHLAAK, J. F. (1998). Mycophenolate Mofetil for Treatment of Active Inflammatory Bowel Disease: Clinical and Immunological Studies. Ann. N. Y. Acad. Sci. 859: 315-318 [Full Text]  
• Campieri, M, Ferguson, A, Doe, W, Persson, T, Nilsson, L-G, the Global Budesonide Study Group, (1997). Oral budesonide is as effective as oral prednisolone in active Crohn's disease. Gut 41: 209-214 [Abstract] [Full Text]  
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