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Previous Volume 331:875-876 September 29, 1994 Number 13 Next

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Thrombocytopenia has been a major problem in the treatment of patients undergoing bone marrow transplantation or chemotherapy for cancer. Thrombopoietin, the hormone thought to stimulate the production and maturation of megakaryocytes (Figure 1), which in turn produce platelets, has recently been purified and cloned^1,2,3,4. This discovery may lead to advances in the treatment of thrombocytopenia caused by deficient production of platelets.

View larger version (151K): [in this window] [in a new window]   Figure 1. Presumed Interaction of the mpl Receptor (orange V) and Its Ligand, Thrombopoietin (solid triangle), to Promote the Proliferation and Maturation of Megakaryocytes.

 
The recovery of platelets after bone marrow transplantation or chemotherapy often occurs later (23 . . . [Full Text of this Article]

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