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Previous Volume 331:918-921 October 6, 1994 Number 14 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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Common variable immunodeficiency is a primary immunodeficiency disease characterized by low serum concentrations of IgG, IgA, and usually IgM^1,2. Although some patients appear to have only intrinsic B-cell defects, more than half also have abnormalities of T-cell activation and deficient secretion of interferon- and interleukin-2, -4, and -5^3,4,5,6,7. Most patients also have deficient production of a B-cell differentiation factor, a 34-kd protein that has been purified and lacks interleukin-2, -4, -6, and -10 activity⁸. We and others hypothesized that the B cells in this disease may be defective because of a lack of essential cytokines^9,10,11,12. Because . . . [Full Text of this Article]

Case Report

Methods

Protocol for PEG-Conjugated Interleukin-2

Lymphocyte Populations and Proliferation

Assays for Interleukin-2, Interleukin-6, and B-Cell Differentiation Factor

In Vitro Immunoglobulin Production

Serum Immunoglobulins and Antibody Production

Results

Lymphocyte Proliferation

Production of Interleukin-2 and Interleukin-6

B-Cell Differentiation Factor

Serum Immunoglobulins and Antibody Production

Clinical Effect

Discussion

Source Information

From the Division of Clinical Immunology, Department of Medicine, Mount Sinai Medical Center, 1 Gustave Levy Pl., New York, NY 10029, where reprint requests should be addressed to Dr. Cunningham-Rundles.

References

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• Borte, S., Pan-Hammarstrom, Q., Liu, C., Sack, U., Borte, M., Wagner, U., Graf, D., Hammarstrom, L. (2009). Interleukin-21 restores immunoglobulin production ex vivo in patients with common variable immunodeficiency and selective IgA deficiency. Blood 114: 4089-4098 [Abstract] [Full Text]  
• Chapes, S. K., Simske, S. J., Sonnenfeld, G., Miller, E. S., Zimmerman, R. J. (1999). Effects of spaceflight and PEG-IL-2 on rat physiological and immunological responses. J. Appl. Physiol. 86: 2065-2076 [Abstract] [Full Text]  
• Aukrust, P., Aandahl, E. M., Skalhegg, B. S., Nordoy, I., Hansson, V., Tasken, K., Froland, S. S., Muller, F. (1999). Increased Activation of Protein Kinase A Type I Contributes to the T Cell Deficiency in Common Variable Immunodeficiency. J. Immunol. 162: 1178-1185 [Abstract] [Full Text]  
• Levy, Y., Gupta, N., Le Deist, F., Garcia, C., Fischer, A., Weill, J.-C., Reynaud, C.-A. (1998). Defect in IgV gene somatic hypermutation in Common Variable Immuno-Deficiency syndrome. Proc. Natl. Acad. Sci. USA 95: 13135-13140 [Abstract] [Full Text]