FREE NEJM E-TOC    HOME   |   SUBSCRIBE   |   CURRENT ISSUE   |   PAST ISSUES   |   COLLECTIONS   |   Search Term  Advanced Search

Sign in | Get NEJM's E-Mail Table of Contents — Free | Subscribe

Previous Volume 331:949-951 October 6, 1994 Number 14 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

	Full Text Purchase this article Add to Personal Archive Add to Citation Manager Notify a Friend E-mail When Cited Related Article by Saffran, D. C. PubMed Citation

To the Editor: The Brief Report by Saffran et al.¹ and the companion editorial by Buckley² (May 26 issue) concern the effects of mutations in the gene for Bruton's tyrosine kinase (Btk)^3,4 on the phenotypic expression of X-linked agammaglobulinemia. We take exception to Dr. Buckley's conclusion that less severe (atypical) X-linked agammaglobulinemia may be associated with changes in non-kinase regions of Btk.

Recently, we evaluated eight patients in whom six different mutations in the Btk gene have been identified⁵. In one of our patients, Btk transcripts lacked the exon encoding most of the kinase domain, had a frame shift, . . . [Full Text of this Article]

References

This article has been cited by other articles:

• Cronin, F. E., Jiang, M., Abbas, A. K., Grupp, S. A. (1998). Role of {micro} Heavy Chain in B Cell Development. I. Blocked B Cell Maturation But Complete Allelic Exclusion in the Absence of Ig{alpha}/{beta}. J. Immunol. 161: 252-259 [Abstract] [Full Text]  
• Sicherer, S. H., Winkelstein, J. A. (1998). Primary Immunodeficiency Diseases in Adults. JAMA 279: 58-61 [Full Text]