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Previous Volume 331:951 October 6, 1994 Number 14 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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To the Editor: Cockcroft et al. (April 14 issue) report preserved endothelium-dependent vasodilatation in response to carbachol and acetylcholine in patients with essential hypertension¹. In repeated studies, however, my colleagues and I have consistently found a depressed response to acetylcholine in patients with hypertension, a finding reproduced by several other investigators, even in a study of human arteries in vitro². More recently, we have demonstrated that such impaired vascular responses also extend to other endothelium-dependent agonists, such as substance P³ and bradykinin⁴. We have certainly found variation in the response to acetylcholine among hypertensive patients and have . . . [Full Text of this Article]

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