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Previous Volume 331:1019-1020 October 13, 1994 Number 15 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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To the Editor: In their fine review of histamine H₁-receptor-antagonist drugs (June 9 issue),¹ Simons and Simons do not mention doxepin, a potent and useful H₁-receptor antagonist. Although it is not typically placed in this pharmacologic group, doxepin binds with high affinity to brain H₁ receptors.² This agent is clinically useful when delivered by either the systemic or topical route.^3,4 Like many of the other agents discussed in the review, doxepin has a wide variety of side effects, including xerostomia and postural hypotension. Nevertheless, because of its high potency, it deserves to be included in our antihistamine armamentarium.

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