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Correspondence
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Volume 331:1022-1023 October 13, 1994 Number 15
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Mortality in Sickle Cell Disease

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 by Platt, O. S.
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To the Editor: The article by Platt et al. (June 9 issue)1 described the risk factors associated with early death in patients with sickle cell disease -- specifically, they found that, of the 69 "healthy" patients with sickle cell anemia who died, approximately 22 percent had acute strokes. Recently, we reported that "relative" hypertension, defined by patient-based normative standards in a group of 89 patients homozygous for sickle cell disease, was significantly associated with stroke in patients older than 20 years of age.2 The elevated blood pressure in this group was in a range that would be considered normal on . . . [Full Text of this Article]

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