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Previous Volume 331:1072-1078 October 20, 1994 Number 16 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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Conception is followed by a series of hormonal and metabolic changes that involve most maternal endocrine systems. With regard to thyroid metabolism, these include an increase in serum thyroxine-binding globulin and thyroid hormone concentrations, increased renal clearance of iodine, and increased production and turnover of thyroxine (T)¹. Fetal and maternal thyroid physiology differ, but the systems interact by means of the placenta and amniotic fluid, which modulate the transfer of iodine and small but important amounts of thyroid hormone from mother to fetus^1,2. In this article we shall review recent data and new insights regarding the changes in . . . [Full Text of this Article]

Thyroid Function in Pregnant Women

The Placenta

Metabolism of Iodothyronines

The Placenta as a Barrier to Maternal-Fetal Flux of Thyroid Hormones

Thyroid Hormones in the Fetus

Development of Fetal Thyroid Function

Metabolism of Iodothyronines

The Importance of Iodothyronines in Amniotic Fluid

Effects of Thyroid Hormone on the Fetus and Neonate

Conclusions

Source Information

From the Department of Medicine, Yale University School of Medicine, New Haven, Conn. (G.N.B.); Corning Nichols Institute, San Juan Capistrano, Calif. (D.A.F.); and the Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston (P.R.L.).

Address reprint requests to Dr. Fisher at Corning Nichols Institute, 33608 Ortega Hwy., San Juan Capistrano, CA 92690.

References

Related Letters:

Maternal and Fetal Thyroid Function
Snitzer J. L., Burrow G. N., Fisher D. A., Larsen P. R.
Extract | Full Text  
N Engl J Med 1995; 332:613-614, Mar 2, 1995. Correspondence

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• Ehrlich, R. M. (1995). Thyroxine Dose for Congenital Hypothyroidism. CLIN PEDIATR 34: 521-522  
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