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Previous Volume 331:1096-1097 October 20, 1994 Number 16 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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To the Editor: To find linkage between the angiotensinogen gene and essential hypertension in one underpowered study¹ and its subgroups requires good fortune; to present a second with still less power demands fortitude.² The demonstration of linkage rests on a difference between the observed number of alleles of the angiotensinogen gene shared in hypertensive sibships and an estimate of the number expected.³ That the study by Caulfield et al. (June 9 issue)² lacks power is illustrated by calculations that can be made for a totally polymorphic marker.⁴ Assuming that such a marker is linked to hypertension in 20 percent of . . . [Full Text of this Article]

References

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• Rogus, J. J., Moczulski, D., Freire, M. B. S., Yang, Y., Warram, J. H., Krolewski, A. S. (1998). Diabetic Nephropathy Is Associated With AGT Polymorphism T235 : Results of a Family-Based Study. Hypertension 31: 627-631 [Abstract] [Full Text]  
• Sato, N., Katsuya, T., Rakugi, H., Takami, S., Nakata, Y., Miki, T., Higaki, J., Ogihara, T. (1997). Association of Variants in Critical Core Promoter Element of Angiotensinogen Gene With Increased Risk of Essential Hypertension in Japanese. Hypertension 30: 321-325 [Abstract] [Full Text]