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Correspondence
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Volume 331:1235 November 3, 1994 Number 18
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Systemic Lupus Erythematosus

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To the Editor: We believe that some important aspects of the immunogenetics and the pathogenesis of systemic lupus erythematosus (SLE) are missing in the review article by Mills on SLE (June 30 issue).1 Mills states that many clinical manifestations of SLE are the consequence of tissue damage from vasculopathy mediated by immune complexes. In this context he should mention the important link between complement deficiencies and SLE. The strongest disease-susceptibility genes to be identified in humans are those encoding deficiencies of proteins of the classic pathway of complement, especially C1q, C2, and C4.2,3 Over 75 percent of patients with a . . . [Full Text of this Article]

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