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Previous Volume 331:1272-1285 November 10, 1994 Number 19 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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Although the rate of acute severe adverse cutaneous reactions to medications is low, these reactions can affect anyone who takes medications and can result in death or disability¹. Even a small number of cases associated with a particular drug may alter the recommendations for its use^2,3,4. Prompt differentiation of severe adverse cutaneous reactions from less serious skin disorders may be difficult. Rapid recognition of severe reactions is essential. Prompt withdrawal of the offending drug is often the most important action to minimize morbidity.

Adverse cutaneous reactions to drugs are frequent, affecting 2 to 3 percent of hospitalized patients⁵. . . [Full Text of this Article]

Recognition

Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis

Clinical Features

Differential Diagnosis

Epidemiologic Features

Pathophysiology

Prognosis and Treatment

Hypersensitivity Syndrome

Vasculitis and Serum Sickness

Clinical Presentation

Differential Diagnosis

Anticoagulant-Induced Skin Necrosis

Angioedema

Conclusions

Source Information

From the Department of Dermatology, Henri Mondor Hospital, University of Paris XII, Creteil, France (J.C.R.), and Beth Israel Hospital, Harvard Medical School, Boston (R.S.S.).

Address reprint requests to Dr. Stern at the Department of Dermatology, Beth Israel Hospital, 330 Brookline Ave., Boston, MA 02215.

References

Related Letters:

Severe Adverse Cutaneous Reactions to Drugs
Fernández-Fernández F. J., Garrido J.A., Hauben M., Drenth J. P.H., Michiels J. J., Hughes-Davies L., Stern R. S., Roujeau J. C.
Extract | Full Text  
N Engl J Med 1995; 332:959-960, Apr 6, 1995. Correspondence

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