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Previous Volume 331:131-132 July 14, 1994 Number 2 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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To the Editor: Rodin et al. (Feb. 17 issue)¹ postulate the dysregulation of 11-hydroxysteroid dehydrogenase in some women with the polycystic ovary syndrome. The interconversion of cortisol and hormonally inactive cortisone is catalyzed by at least two isoforms of 11-hydroxysteroid dehydrogenase, a nicotinamide-adenine dinucleotide-dependent, unidirectional dehydrogenase (type 2) found predominantly in the placenta and kidneys, and the type 1 enzyme, which has both NADP-dependent dehydrogenase and 11-oxo-reductase activity and is found predominantly in the liver and gonads. The contribution of each type of enzyme to the urinary ratios of 11-oxo to 11-hydroxy metabolites of cortisol and corticosterone used . . . [Full Text of this Article]

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