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Previous Volume 331:85-87 July 14, 1994 Number 2 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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Disseminated acanthamoeba infection, an amebic infection characterized by granulomatous infiltrates in the brain and skin, usually occurs in immunocompromised or debilitated patients and generally progresses to death. There has been no effective therapy. We report on a patient who had undergone renal transplantation and was receiving triple immunosuppressive therapy when widespread granulomatous skin lesions caused by Acanthamoeba rhysodes developed. Antimicrobial therapy was initiated with a four-week course of intravenous pentamidine isethionate, topical chlorhexidine gluconate, and 2 percent ketoconazole cream. The result was a dramatic improvement in the skin lesions. Cyclosporine levels remained stable, but therapy was complicated by signs of . . . [Full Text of this Article]

Case Report

Discussion

Source Information

From the Departments of Dermatology (C.A.S., A.A.G.), Pathology (J.Z.S.), and Medicine, Nephrology Unit (R.C.P.), University of Rochester Medical Center, Rochester, N.Y.; and the Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta (G.S.V.).

Address reprint requests to Dr. Gaspari at the University of Rochester Medical Center, 601 Elmwood Ave., Box 697, Rochester, NY 14642.

References

Related Letters:

Laundry Brighteners and Amebic Cysts
Wilhelmus K. R., Osato M. S., Gaspari A. A., Slater C. A., Visvesvara G. S.
Extract | Full Text  
N Engl J Med 1994; 331:1459, Nov 24, 1994. Correspondence

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