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Previous Volume 331:1343-1346 November 17, 1994 Number 20 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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Whipple's disease is a systemic infection characterized most commonly by fever, weight loss, diarrhea, polyarthritis, and adenopathy^1,2. Attempts to culture the causative organism have been unsuccessful, but microscopical examination of infected tissue, usually small-bowel-biopsy specimens or lymph nodes, reveals small gram-positive rods that appear as diastase-resistant intracytoplasmic inclusions on periodic acid-Schiff staining². Electron microscopy reveals that these organisms possess a trilamellar membrane external to the cell wall, a finding usually associated with gram-negative bacteria^3,4.

Recent studies have shown that the specific identification of bacterial pathogens does not require culture but can be accomplished by molecular analysis of . . . [Full Text of this Article]

Case Reports

Case 1

Case 2

Methods

Microscopical Studies

Molecular Studies

Results

Discussion

Source Information

From the Departments of Medicine (R.L., G.F., M.M., J.C., H.M., H.A.) and Laboratory Medicine (B.P.), Princess Margaret Hospital and the University of Toronto, Toronto; the Department of Microbiology, Princess Margaret-Mount Sinai Hospitals and the University of Toronto, Toronto (B.M.W., A.M.); and the Department of Medicine, Division of Infectious Diseases, Medical College of Virginia, Virginia Commonwealth University, Richmond (G.L.A.).

Address reprint requests to Dr. McGeer at Princess Margaret Hospital, 500 Sherbourne St., Toronto, ON M4X 1K9, Canada.

References

This article has been cited by other articles:

• Dutly, F., Altwegg, M. (2001). Whipple's Disease and ""Tropheryma whippelii"". Clin. Microbiol. Rev. 14: 561-583 [Abstract] [Full Text]  
• Messori, A., Bella, P. D., Polonara, G., Logullo, F., Pauri, P., Haghighipour, R., Salvolini, U. (2001). An Unusual Spinal Presentation of Whipple Disease. Am. J. Neuroradiol. 22: 1004-1008 [Abstract] [Full Text]  
• Kremer, S., Besson, G., Bonaz, B., Pasquier, B., Le Bas, J.-F., Grand, S. (2001). Diffuse Lesions in the CNS Revealed by MR Imaging in a Case of Whipple Disease. Am. J. Neuroradiol. 22: 493-495 [Abstract] [Full Text]  
• Fenollar, F., Raoult, D. (2001). Whipple's Disease. CVI 8: 1-8 [Full Text]  
• Misbah, S A, Mapstone, N P (2000). Whipple's disease revisited. J. Clin. Pathol. 53: 750-755 [Abstract] [Full Text]  
• Swartz, M. N. (2000). Whipple's Disease -- Past, Present, and Future. NEJM 342: 648-650 [Full Text]  
• ANDERSON, M. (2000). Neurology of Whipple's disease. J. Neurol. Neurosurg. Psychiatry 68: 2-5 [Full Text]  
• Raoult, D. (1999). Afebrile Blood Culture-Negative Endocarditis. ANN INTERN MED 131: 144-146 [Full Text]  
• Bel'eed, K., Kumar, A., Asin, M., Sellars, L., Farmer, C., Goldsmith, D. (1999). Endoluminal brushing of blocked indwelling haemodialysis catheters. Nephrol Dial Transplant 14: 241a-241a  
• Galperin, C., Gershwin, M. E. (1997). Immunopathogenesis of Gastrointestinal and Hepatobiliary Diseases. JAMA 278: 1946-1955 [Abstract]  
• Rickman, L. S., Freeman, W. R., Green, W. R., Feldman, S. T., Sullivan, J., Russack, V., Relman, D. A. (1995). Uveitis Caused by Tropheryma whippelii (Whipple's Bacillus). NEJM 332: 363-366 [Full Text]