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Previous Volume 331:1447-1449 November 24, 1994 Number 21 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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Several genetic diseases can have the clinical features of either a generalized condition or a disorder with an alternating pattern of affected and unaffected body segments. With skin disorders, in which the segmental expression of symptoms is most easily observed, the pattern of affected and healthy skin often follows the so-called lines of Blaschko. Such mosaic patterns have long been assumed to reflect mutations occurring after fertilization. These postzygotic mutations result in genetic mosaicism -- a condition in which people have a mixture of genetically distinct cell populations (Figure 1). The article by Paller and colleagues in this . . . [Full Text of this Article]

References

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