To the Editor: Although distal renal tubular acidosis is oftenassociated with immune-mediated diseases, autoantibodies againstrenal tubular cells have been detected only sporadically.1,2,3We report the case of a 34-year-old woman with Graves' hyperthyroidismand distal renal tubular acidosis whose serum contained antibodiesto renal collecting-duct cells.
In August 1989 weight loss and palpitation occurred in the patient.She had exophthalmos, diffuse goiter, and elevated serum thyroidhormone concentrations. She was treated with methimazole andbecame euthyroid. In June 1991 progressive weakness of the extremitiesdeveloped over a period of several days. The patient was taking2.5 mg of . . . [Full Text of this Article]
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