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Previous Volume 331:222-227 July 28, 1994 Number 4 Next

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ABSTRACT

Background The ability of the coronary vascular bed to dilate and thus increase blood flow to the myocardium may be impaired in coronary artery disease, even in regions of myocardium supplied by an angiographically normal coronary artery. If this kind of vasomotor dysfunction was present or accentuated after acute myocardial infarction, it might influence the extent of ischemia and necrosis in areas not directly injured by the infarction.

Methods We studied 13 patients (mean [±SD] age, 62 ±11 years) with single-vessel coronary artery disease after they had received thrombolytic therapy for myocardial infarction. Using positron-emission tomography (PET) with oxygen-15-labeled water, we measured regional myocardial blood flow under basal conditions and after the intravenous administration of dipyridamole (0.5 mg per kg of body weight over a period of four minutes) 8 ±3 days after infarction in all 13 patients (1-week study) and 6 ±2 months after infarction in 9 of the 13 (6-month study). On both occasions we measured blood flow both in the infarcted region and in a region of myocardium that was remote from the infarcted region and supplied by a normal artery.

Results At the one-week PET study, the coronary vasodilator response (the ratio of the myocardial blood flow after the administration of dipyridamole to basal blood flow) was 1.12 ±0.50 in the infarct-related artery and 1.53 ±0.36 in the remote region (P = 0.015). At the six-month study, the coronary vasodilator response was 1.42 ±0.37 in the infarcted region and 2.19 ±0.69 in the remote region (P = 0.004 for the comparison with the infarcted region; P = 0.011 for the comparison with the remote region at the one-week study). The value in remote myocardium remained lower than that in similar regions in 10 control patients, who had single-vessel coronary artery disease but no evidence of myocardial infarction (3.17 ±0.72; P = 0.009).

Conclusions After acute myocardial infarction, there is a severe vasodilator abnormality involving not only resistance vessels in infarcted myocardium, but also those in myocardium perfused by normal coronary vessels. This dysfunction may affect the extent of myocardial ischemia and necrosis after coronary occlusion.

Source Information

From the Division of Cardiology (N.G.U., T.C., D.C.L., G.J.D., A.M.) and the Medical Research Council Cyclotron Unit, Hammersmith Hospital, London (R.S.).

Address reprint requests to Dr. Uren at the Department of Cardiology, Glenfield General Hospital, Groby Rd., Leicester LE3 9QF, United Kingdom.

Full Text of this Article

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Reduced Coronary Vasodilator Function after Myocardial Infarction
Bauer J. A., Uren N. G., Lefroy D. C., Crake T.
Extract | Full Text  
N Engl J Med 1994; 331:1590-1591, Dec 8, 1994. Correspondence

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