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Previous Volume 331:234-237 July 28, 1994 Number 4 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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In 1990, more than 27,000 patients died of liver failure in the United States¹. Perfusion through a liver from another person or a member of another species, such as a monkey, outside the body was used in the past to stabilize the condition of some patients with acute or subacute liver failure^2,3,4,5. Few patients survived, however, and this approach was superseded by orthotopic liver transplantation⁶. Liver transplantation is associated with higher mortality for patients with fulminant hepatic failure than for patients with chronic liver disease, however. Patients with fulminant hepatic failure often have multiorgan failure and hemodynamic . . . [Full Text of this Article]

Methods

Consent

Procurement of Pig Livers

Preparation of Patients and Perfusion Circuit

Stages of Hepatic Encephalopathy

Case Reports

Patient 1

Patient 2

Patient 3

Patient 4

Discussion

Source Information

From the Departments of Surgery (R.S.C., B.H.C., J.C.M., J.M.D., A.D.K., R.C.H., R.L.M., J.L.P., W.C.M.), Immunology (J.L.P.), and Pediatrics (J.L.P.), Duke University Medical Center and Durham Veterans Affairs Medical Center, Durham, N.C. Presented in part at the 19th Annual Scientific Meeting of the American Society of Transplant Surgeons, Houston, May 20-22, 1993.

Address reprint requests to Dr. Meyers at Box 3041, Duke University Medical Center, Durham, NC 27710.

References

This article has been cited by other articles:

• Grosse-Siestrup, C., Pfeffer, J., Unger, V., Nagel, S., Witt, C., Fischer, A., Groneberg, D. A. (2002). Isolated Hemoperfused Slaughterhouse Livers as a Valid Model to Study Hepatotoxicity. Toxicol Pathol 30: 749-754 [Abstract]  
• Lee, J.-H., Webb, G. C., Allen, R. D. M., Moran, C. (2002). Characterizing and Mapping Porcine Endogenous Retroviruses in Westran Pigs. J. Virol. 76: 5548-5556 [Abstract] [Full Text]  
• Groneberg, D. A., Grosse-Siestrup, C., Fischer, A. (2002). In Vitro Models to Study Hepatotoxicity. Toxicol Pathol 30: 394-399 [Abstract]  
• Chapman, L. E., Bloom, E. T. (2001). Clinical Xenotransplantation. JAMA 285: 2304-2306 [Full Text]  
• Qari, S. H., Magre, S., García-Lerma, J. G., Hussain, A. I., Takeuchi, Y., Patience, C., Weiss, R. A., Heneine, W. (2001). Susceptibility of the Porcine Endogenous Retrovirus to Reverse Transcriptase and Protease Inhibitors. J. Virol. 75: 1048-1053 [Abstract] [Full Text]  
• Adams, D. H., Chen, R. H., Kadner, A. (2000). Cardiac xenotransplantation: clinical experience and future direction. Ann. Thorac. Surg. 70: 320-326 [Abstract] [Full Text]  
• Czauderna, F., Fischer, N., Boller, K., Kurth, R., Tönjes, R. R. (2000). Establishment and Characterization of Molecular Clones of Porcine Endogenous Retroviruses Replicating on Human Cells. J. Virol. 74: 4028-4038 [Abstract] [Full Text]  
• Clark, M. A. (1999). This Little Piggy Went to Market: The Xenotransplantation and Xenozoonose Debate. J Law Med Ethics 27: 137-152  
• Chapman, L. E., Folks, T. M., Salomon, D. R., Patterson, A. P., Eggerman, T. E., Noguchi, P. D. (1995). Xenotransplantation and Xenogeneic Infections. NEJM 333: 1498-1501 [Full Text]  
• Cattral, M. S., Levy, G. A. (1994). Artificial Liver Support -- Pipe Dream or Reality?. NEJM 331: 268-269 [Full Text]