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Correspondence
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Volume 331:272-274 July 28, 1994 Number 4
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Riluzole in Amyotrophic Lateral Sclerosis

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by Tobin, M. J.
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by Bensimon, G.
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To the Editor: In the study of riluzole in amyotrophic lateral sclerosis by Bensimon et al. (March 3 issue),1 24 patients (15.5 percent of all patients) were included who did not meet the stringent inclusion criteria. Without this group, the differences in the major end points did not reach statistical significance. The investigators made a decision when they were still blinded to the treatment assignments to include this group. They do not describe how the patients failed to meet the criteria. Since the inclusion of these patients is critical to the chief findings in the study, it is essential that . . . [Full Text of this Article]

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