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Previous Volume 331:276 July 28, 1994 Number 4 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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To the Editor: In their 1991 article on clozapine (March 14, 1991, issue),¹ Drs. Baldessarini and Frankenburg stated, "Other trends noted with clozapine include somewhat (20 to 30 percent) higher plasma levels in women and smokers and up to twofold increases between young and older adults." In the reference² cited for this statement, Haring et al. reported that the plasma levels of clozapine are lower in smokers than in nonsmokers, and higher in older than in younger patients.

Olga Delgado Sanchez, Pharm.D.
M. Carmen Puerta Fernandez, Pharm.D.
Servicio de Ordenacion Farmaceutica
28009 Madrid, Spain

References

1. Baldessarini RJ, Frankenburg FR. Clozapine: a novel antipsychotic agent. N Engl J Med 1991;324:746-754. [Medline]
2. Haring C, Meise U, Humpel C, Saria A, Fleischhacker WW, Hinterhuber H. Dose-related plasma levels of clozapine: influence of smoking behaviour, sex and age. Psychopharmacology (Berl) 1989;99:Suppl:S38-S40.

To the Editor: . . . [Full Text of this Article]

References

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