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Previous Volume 331:377-382 August 11, 1994 Number 6 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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The resistance of Streptococcus pneumoniae to penicillin and other antimicrobial agents is increasing in many parts of the world. The frequency of erythromycin resistance in parts of Europe¹ and, to a lesser extent, in the United States² limits the usefulness of macrolide antibiotics for the treatment of pneumonia, and resistance to trimethoprim-sulfamethoxazole, chloramphenicol, and tetracycline is an important problem in some other countries^3,4. Recently, resistance to and clinical failure of the extended-spectrum cephalosporins ceftriaxone and cefotaxime in the treatment of pneumococcal meningitis have been noted in Spain^5,6 and the United States^7,8. In addition, there have been reports of . . . [Full Text of this Article]

Definition and Prevalence of Resistance

The Spread of Resistance

Effects of Penicillin Resistance in S. Pneumoniae on the Presentation and Severity of Disease

Susceptibility of Penicillin-Resistant S. Pneumoniae to Other Antibiotics

Antimicrobial Therapy for Penicillin-Resistant Pneumococcal Infections

Meningitis

            Chloramphenicol

            Cephalosporin and Other Antimicrobial Agents

Sepsis and Pneumonia

Otitis Media

            Alternative Therapy for Otitis Media

Summary

Source Information

From the Department of Pediatrics, Baragwanath Hospital, and the University of the Witwatersrand, Johannesburg, South Africa (I.R.F.); and the Department of Pediatrics, Division of Infectious Disease, University of Texas Southwestern Medical Center, Dallas (G.H.M.).

Address reprint requests to Dr. Friedland at the Department of Pediatrics, Baragwanath Hospital, P.O. Bertsham, Johannesburg 2013, South Africa.

References

Related Letters:

Management of Infections Caused by Antibiotic-Resistant Streptococcus pneumoniae
Rahal J. J., Hodes R. J., Strikas R. A., Hill J. C., Friedland I. R., McCracken G. H.
Extract | Full Text  
N Engl J Med 1994; 331:1774-1775, Dec 29, 1994. Correspondence

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