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Correspondence
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Volume 331:402-404 August 11, 1994 Number 6
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Adjuvant Systemic Therapy and Survival after Breast Cancer

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 by Olivotto, I. A.
To the Editor: Olivotto and colleagues (March 24 issue)1 attempt to isolate the effects of policies regarding treatment by choosing single years in which other factors that might influence survival, such as screening activity, are thought to be approximately constant. This approach can never be entirely satisfactory, since survival rates are the products of complex processes involving the quality of data (the completeness of registration, the accuracy of recorded diagnoses, changes in the classification of tumors, and the completeness of follow-up), statistical artifacts (lead-time bias), host factors (improved general health and greater public awareness of cancer), and health care factors . . . [Full Text of this Article]

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