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Correspondence
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Volume 331:482 August 18, 1994 Number 7
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Varicella Infection in Pregnancy

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 by Pastuszak, A. L.
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To the Editor: Pastuszak and her colleagues (March 31 issue)1 report embryopathy in 1 of 49 infants born alive after first-trimester maternal varicella. In the meta-analysis of their own results and those of four comparable published studies, they calculate a 2.2 percent aggregate mean rate of congenital varicella embryopathy among such live-born infants. Their Table 4 shows the fetal risk for the congenital varicella syndrome in each study. However, according to the references cited, only 1 of 145 cases in the table involved defects typical of the syndrome. The authors' case may be added, but it is not clear whether . . . [Full Text of this Article]

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