FREE NEJM E-TOC    HOME   |   SUBSCRIBE   |   CURRENT ISSUE   |   PAST ISSUES   |   COLLECTIONS   |   Search Term  Advanced Search

Sign in | Get NEJM's E-Mail Table of Contents — Free | Subscribe

Previous Volume 331:609-610 September 1, 1994 Number 9 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

	Full Text Purchase this article Add to Personal Archive Add to Citation Manager Notify a Friend E-mail When Cited PubMed Citation

-Thalassemia is one of the most common single-gene disorders. More than 100 mutations in or around the -globin gene are known to cause decreased production of -globin, which in turn leads to the excess accumulation of unstable -globin chains, ineffective erythropoiesis, and shortened red-cell survival. Although the clinical severity of -thalassemia varies considerably, most patients who are homozygous for -thalassemia become dependent on transfusions and thus have the transfusion-related complications of iron overload, alloimmunization, and viral infection. Recent advances in basic and clinical research offer the clinician not only new approaches to the treatment of these patients but also the . . . [Full Text of this Article]

References

This article has been cited by other articles:

• Horwitz, L. D, Rosenthal, E. A (1999). Iron-mediated cardiovascular injury. Vasc Med 4: 93-99 [Abstract]  
• Chui, D. H.K., Waye, J. S. (1998). Hydrops Fetalis Caused by alpha -Thalassemia: An Emerging Health Care Problem. Blood 91: 2213-2222 [Full Text]  
• Lau, Y.-L., Chan, L.-C., Chan, Y.-Y. A., Ha, S.-Y., Yeung, C.-Y., Waye, J. S., Chui, D. H.K. (1997). Prevalence and Genotypes of {alpha}- and {beta}-Thalassemia Carriers in Hong Kong -- Implications for Population Screening. NEJM 336: 1298-1301 [Abstract] [Full Text]