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Previous Volume 332:45-47 January 5, 1995 Number 1 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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A fundamental component of the complex instructions for building and maintaining an organism is the regulation of gene expression. The rules governing gene transcription explain why neurons and osteoclasts have completely different forms and functions even though all the nucleated cells in a person contain the same DNA and thus the same genetic information. A neuron is neither an osteoclast nor a granulocyte because of the neuron-specific pattern of gene transcription it elaborates over time and in particular anatomical spaces. The regulation of gene expression comes into play in circumstances as wide-ranging as the maturation of antibody-secreting cells, the production . . . [Full Text of this Article]

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From the Differentiation Program of the European Molecular Biology Laboratory, Postfach 102209, D-69012 Heidelberg, Germany, where reprint requests should be addressed to Dr. Papavassiliou.

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