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Previous Volume 332:60-62 January 5, 1995 Number 1 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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To the Editor: Rothman and Michels (Aug. 11 issue)¹ object to the practice of giving "individual investigators and . . . institutional review boards the right to determine how much discomfort or temporary disability patients should endure for the purpose of research." Regardless of what controls are used, precisely such a determination must be made concerning the foreseeable adverse effects of the treatment under study and the observation procedures. Is it really worse to ask an informed patient to volunteer to forgo treatment of mild hypertension for a few weeks than to ask a research subject to undergo a radiologic . . . [Full Text of this Article]

References

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• Khan, A., Warner, H. A., Brown, W. A. (2000). Symptom Reduction and Suicide Risk in Patients Treated With Placebo in Antidepressant Clinical Trials: An Analysis of the Food and Drug Administration Database. Arch Gen Psychiatry 57: 311-317 [Abstract] [Full Text]  
• Jones, B, Jarvis, P, Lewis, J A, Ebbutt, A F (1996). Trials to assess equivalence: the importance of rigorous methods. BMJ 313: 36-39 [Full Text]