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Previous Volume 332:679-680 March 9, 1995 Number 10 Next

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The term "complex disease" has been coined for conditions that arise from multifaceted interactions of environmental and heritable factors. It encompasses some of the most common disorders, such as hypertension, ischemic heart disease, and obesity. The heritability of these disorders deviates in important ways from that of classic, (mono)genetic diseases: no simple mendelian mode of transmission is apparent, and the severity of the disorders shows quantitative, unimodal variation rather than a dichotomous distribution. Complex traits are regarded as polygenic and multifactorial, with the phenotype representing the net effect of all contributing genes and environmental factors. These characteristics render the hunt . . . [Full Text of this Article]

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