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Correspondence
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Volume 332:685-686 March 9, 1995 Number 10
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Chronic Idiopathic Thrombocytopenic Purpura

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 by George, J. N.
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To the Editor: I believe that an important aspect of laboratory evaluation and differential diagnosis is missing from the review article by George et al. (Nov. 3 issue)1 on chronic idiopathic thrombocytopenic purpura (ITP). Abnormalities of platelet size and morphology are common in ITP. The widespread availability of particle counters in clinical laboratories now permits accurate measurement of the mean platelet volume and the extent of heterogeneity in platelet size on the basis of the platelet-distribution width. Estimates of mean platelet volume and platelet-distribution width provide useful information for evaluating patients with ITP.2 There is accelerated production of platelets in . . . [Full Text of this Article]

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