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Editorial
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Volume 332:739-740 March 16, 1995 Number 11
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Primary Prophylaxis against Opportunistic Infections in Patients with AIDS

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Human immunodeficiency virus (HIV) infection has become a chronic disease that lasts at least 10 to 15 years. One of the major clinical advances has been the implementation in the mid-1980s of antimicrobial prophylaxis for patients with severe immune impairment. Together with the use of antiretroviral drugs, this prophylaxis has led to decreased morbidity and improved survival among patients with AIDS. So far, recommendations have been issued for primary prophylaxis against Pneumocystis carinii pneumonia, infection with Mycobacterium avium complex, and tuberculosis. There are reports and ongoing studies of strategies for preventing infections caused by Toxoplasma gondii, cytomegalovirus, and some fungi. . . . [Full Text of this Article]

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