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Previous Volume 332:817-818 March 23, 1995 Number 12 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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The failing heart is a challenge to clinicians, scientists, and those who grapple with the problems of economics and equity in the provision of medical services. Numerically, the problem is enormous: 400,000 new cases and $10.2 billion in direct medical costs in the United States annually. Current forms of treatment are reasonable but have a limited impact on the overall human and monetary costs of this condition. Cardiac transplantation provides definitive therapy with acceptable risks, but the costs are high and donor hearts are available for only a tiny fraction of the patients in need. Medical therapy for heart failure . . . [Full Text of this Article]

References

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• Hata, J. A., Koch, W. J. (2003). Phosphorylation of G Protein-Coupled Receptors: GPCR Kinases in Heart Disease. Mol. Interv. 3: 264-272 [Abstract] [Full Text]  
• Maurice, J. P., Shah, A. S., Kypson, A. P., Hata, J. A., White, D. C., Glower, D. D., Koch, W. J. (1999). Molecular beta -adrenergic signaling abnormalities in failing rabbit hearts after infarction. Am. J. Physiol. Heart Circ. Physiol. 276: H1853-H1860 [Abstract] [Full Text]  
• Akhter, S. A., Skaer, C. A., Kypson, A. P., McDonald, P. H., Peppel, K. C., Glower, D. D., Lefkowitz, R. J., Koch, W. J. (1997). Restoration of beta -adrenergic signaling in failing cardiac ventricular myocytes via adenoviral-mediated gene transfer. Proc. Natl. Acad. Sci. USA 94: 12100-12105 [Abstract] [Full Text]