Background Since the inflammatory response to chronic infectioncontributes to lung destruction in patients with cystic fibrosis,we hypothesized that antiinflammatory therapy might slow theprogression of lung disease.
Methods In a double-blind trial, 85 patients, 5 to 39 yearsof age, with mild lung disease (forced expiratory volume inone second [FEV1], >60 percent of the predicted value) wererandomly assigned to receive ibuprofen or placebo orally twicedaily for four years. Doses were adjusted individually to achievepeak plasma concentrations of 50 to 100 µg per milliliter.Changes in pulmonary function, the percentage of ideal bodyweight, the chest-radiograph score, and the frequency of hospitalizationwere assessed.
Results Patients randomly assigned to ibuprofen had a slowerannual rate of change in FEV1 than the patients assigned toplacebo (mean [±SE] slope, -2.17±0.57 percentvs. -3.60±0.55 percent in the placebo group; P = 0.02),and weight (as a percentage of ideal body weight) was bettermaintained in the former group (P = 0.02). Among the patientswho took ibuprofen for four years and had at least a 70 percentrate of compliance, the annual rate of change in FEV1 was evenslower (-1.48±0.69 percent vs. -3.57±0.65 percentin the placebo group, P = 0.03), and this group of patientsalso had a significantly slower rate of decline in forced vitalcapacity, the percentage of ideal body weight, and the chest-radiographscore. There was no significant difference between the ibuprofenand placebo groups in the frequency of hospitalization. Onepatient was withdrawn from the study because of conjunctivitis,and one because of epistaxis related to ibuprofen.
Conclusions In patients with cystic fibrosis and mild lung disease,high-dose ibuprofen, taken consistently for four years, significantlyslows the progression of the lung disease without serious adverseeffects.
Source Information
From the Departments of Pediatrics (M.W.K., P.J.B., P.B.D.), Medicine (C.L.H., P.B.D.), and Pharmacology (C.L.H.), Case Western Reserve University School of Medicine, Rainbow Babies and Children's Hospital, and the Veterans Affairs Medical Center, Cleveland.
Address reprint requests to Dr. Konstan at the Rainbow Babies and Children's Hospital, 2101 Adelbert Rd., Cleveland, OH 44106.
Nichols, D. P., Ziady, A. G., Shank, S. L., Eastman, J. F., Davis, P. B.
(2009). The triterpenoid CDDO limits inflammation in preclinical models of cystic fibrosis lung disease. Am. J. Physiol. Lung Cell. Mol. Physiol.
297: L828-L836
[Abstract][Full Text]
Downey, D G, Bell, S C, Elborn, J S
(2009). Neutrophils in cystic fibrosis. Thorax
64: 81-88
[Abstract][Full Text]
John-Aryankalayil, M., Palayoor, S. T., Cerna, D., Falduto, M. T., Magnuson, S. R., Coleman, C. N.
(2009). NS-398, ibuprofen, and cyclooxygenase-2 RNA interference produce significantly different gene expression profiles in prostate cancer cells. Molecular Cancer Therapeutics
8: 261-273
[Abstract][Full Text]
Dasenbrook, E. C., Merlo, C. A., Diener-West, M., Lechtzin, N., Boyle, M. P.
(2008). Persistent Methicillin-resistant Staphylococcus aureus and Rate of FEV1 Decline in Cystic Fibrosis. Am. J. Respir. Crit. Care Med.
178: 814-821
[Abstract][Full Text]
Griese, M., Kappler, M., Gaggar, A., Hartl, D.
(2008). Inhibition of airway proteases in cystic fibrosis lung disease. Eur Respir J
32: 783-795
[Abstract][Full Text]
Li, J., Xiang, Y-Y., Ye, L., Tsui, L-C., MacDonald, J. F., Hu, J., Lu, W-Y.
(2008). Nonsteroidal anti-inflammatory drugs upregulate function of wild-type and mutant CFTR. Eur Respir J
32: 334-343
[Abstract][Full Text]
Perez, A., van Heeckeren, A. M., Nichols, D., Gupta, S., Eastman, J. F., Davis, P. B.
(2008). Peroxisome proliferator-activated receptor-{gamma} in cystic fibrosis lung epithelium. Am. J. Physiol. Lung Cell. Mol. Physiol.
295: L303-L313
[Abstract][Full Text]
Balfour-Lynn, I. M
(2008). Cystic fibrosis papers of the year 2007. JRSM
101: 10-14
[Full Text]
Blohmke, C. J., Victor, R. E., Hirschfeld, A. F., Elias, I. M., Hancock, D. G., Lane, C. R., Davidson, A. G. F., Wilcox, P. G., Smith, K. D., Overhage, J., Hancock, R. E. W., Turvey, S. E.
(2008). Innate Immunity Mediated by TLR5 as a Novel Antiinflammatory Target for Cystic Fibrosis Lung Disease. J. Immunol.
180: 7764-7773
[Abstract][Full Text]
Jarad, N. A., Giles, K.
(2008). Risk factors for increased need for intravenous antibiotics for pulmonary exacerbations in adult patients with cystic fibrosis. Chronic Respiratory Disease
5: 29-33
[Abstract]
Elizur, A., Cannon, C. L., Ferkol, T. W.
(2008). Airway Inflammation in Cystic Fibrosis*. Chest
133: 489-495
[Abstract][Full Text]
Vij, N., Amoako, M. O., Mazur, S., Zeitlin, P. L.
(2008). CHOP Transcription Factor Mediates IL-8 Signaling in Cystic Fibrosis Bronchial Epithelial Cells. Am. J. Respir. Cell Mol. Bio.
38: 176-184
[Abstract][Full Text]
Konstan, M. W., Schluchter, M. D., Xue, W., Davis, P. B.
(2007). Clinical Use of Ibuprofen Is Associated with Slower FEV1 Decline in Children with Cystic Fibrosis. Am. J. Respir. Crit. Care Med.
176: 1084-1089
[Abstract][Full Text]
Flume, P. A., O'Sullivan, B. P., Robinson, K. A., Goss, C. H., Mogayzel, P. J. Jr., Willey-Courand, D. B., Bujan, J., Finder, J., Lester, M., Quittell, L., Rosenblatt, R., Vender, R. L., Hazle, L., Sabadosa, K., Marshall, B.
(2007). Cystic Fibrosis Pulmonary Guidelines: Chronic Medications for Maintenance of Lung Health. Am. J. Respir. Crit. Care Med.
176: 957-969
[Abstract][Full Text]
Mayer-Hamblett, N., Ramsey, B. W., Kronmal, R. A.
(2007). Advancing Outcome Measures for the New Era of Drug Development in Cystic Fibrosis. Proc Am Thorac Soc
4: 370-377
[Abstract][Full Text]
Sagel, S. D., Chmiel, J. F., Konstan, M. W.
(2007). Sputum Biomarkers of Inflammation in Cystic Fibrosis Lung Disease. Proc Am Thorac Soc
4: 406-417
[Abstract][Full Text]
Bell, S. C, Robinson, P. J
(2007). Exacerbations in cystic fibrosis: 2 {middle dot} Prevention. Thorax
62: 723-732
[Abstract][Full Text]
Saadane, A., Masters, S., DiDonato, J., Li, J., Berger, M.
(2007). Parthenolide Inhibits I{kappa}B Kinase, NF-{kappa}B Activation, and Inflammatory Response in Cystic Fibrosis Cells and Mice. Am. J. Respir. Cell Mol. Bio.
36: 728-736
[Abstract][Full Text]
Vanscoy, L. L., Blackman, S. M., Collaco, J. M., Bowers, A., Lai, T., Naughton, K., Algire, M., McWilliams, R., Beck, S., Hoover-Fong, J., Hamosh, A., Cutler, D., Cutting, G. R.
(2007). Heritability of Lung Disease Severity in Cystic Fibrosis. Am. J. Respir. Crit. Care Med.
175: 1036-1043
[Abstract][Full Text]
Seth, D., Chawla, S., Shy, R., Kamat, D.
(2007). Dysphonia. CLIN PEDIATR
46: 283-289
Quann, E. J., Khwaja, F., Zavitz, K. H., Djakiew, D.
(2007). The Aryl Propionic Acid R-Flurbiprofen Selectively Induces p75NTR-Dependent Decreased Survival of Prostate Tumor Cells. Cancer Res.
67: 3254-3262
[Abstract][Full Text]
Elborn, J S, Bell, S C
(2007). Pulmonary exacerbations in cystic fibrosis and bronchiectasis. Thorax
62: 288-290
[Full Text]
Dubin, P. J., Kolls, J. K.
(2007). IL-23 mediates inflammatory responses to mucoid Pseudomonas aeruginosa lung infection in mice. Am. J. Physiol. Lung Cell. Mol. Physiol.
292: L519-L528
[Abstract][Full Text]
Mulheran, M., Hyman-Taylor, P., Tan, K. H.-V., Lewis, S., Stableforth, D., Knox, A., Smyth, A.
(2006). Absence of Cochleotoxicity Measured by Standard and High-Frequency Pure Tone Audiometry in a Trial of Once- versus Three-Times-Daily Tobramycin in Cystic Fibrosis Patients.. Antimicrob. Agents Chemother.
50: 2293-2299
[Abstract][Full Text]
Clayton, A, Knox, A J
(2006). COX-2: a link between airway inflammation and disordered chloride secretion in cystic fibrosis?. Thorax
61: 552-553
[Full Text]
Roca-Ferrer, J, Pujols, L, Gartner, S, Moreno, A, Pumarola, F, Mullol, J, Cobos, N, Picado, C
(2006). Upregulation of COX-1 and COX-2 in nasal polyps in cystic fibrosis. Thorax
61: 592-596
[Abstract][Full Text]
Chen, D. L., Ferkol, T. W., Mintun, M. A., Pittman, J. E., Rosenbluth, D. B., Schuster, D. P.
(2006). Quantifying Pulmonary Inflammation in Cystic Fibrosis with Positron Emission Tomography. Am. J. Respir. Crit. Care Med.
173: 1363-1369
[Abstract][Full Text]
Chen, D. L., Rosenbluth, D. B., Mintun, M. A., Schuster, D. P.
(2006). FDG-PET imaging of pulmonary inflammation in healthy volunteers after airway instillation of endotoxin. J. Appl. Physiol.
100: 1602-1609
[Abstract][Full Text]
Li, Y., Wang, W., Parker, W., Clancy, J. P.
(2006). Adenosine Regulation of Cystic Fibrosis Transmembrane Conductance Regulator through Prostenoids in Airway Epithelia. Am. J. Respir. Cell Mol. Bio.
34: 600-608
[Abstract][Full Text]
Phaff, S. J., Tiddens, H. A. W. M., Verbrugh, H. A., Ott, A.
(2006). Macrolide resistance of Staphylococcus aureus and Haemophilus species associated with long-term azithromycin use in cystic fibrosis. J Antimicrob Chemother
57: 741-746
[Abstract][Full Text]
Walker, N. M., Simpson, J. E., Levitt, R. C., Boyle, K. T., Clarke, L. L.
(2006). Talniflumate Increases Survival in a Cystic Fibrosis Mouse Model of Distal Intestinal Obstructive Syndrome. J. Pharmacol. Exp. Ther.
317: 275-283
[Abstract][Full Text]
O'Sullivan, B. P., Michelson, A. D.
(2006). The Inflammatory Role of Platelets in Cystic Fibrosis. Am. J. Respir. Crit. Care Med.
173: 483-490
[Abstract][Full Text]
Serisier, D. J., Shute, J. K., Hockey, P. M., Higgins, B., Conway, J., Carroll, M. P.
(2006). Inhaled heparin in cystic fibrosis. Eur Respir J
27: 354-358
[Abstract][Full Text]
Que, C, Cullinan, P, Geddes, D
(2006). Improving rate of decline of FEV1 in young adults with cystic fibrosis. Thorax
61: 155-157
[Abstract][Full Text]
Street, M. E, Ziveri, M. A, Spaggiari, C., Viani, I., Volta, C., Grzincich, G. L., Virdis, R., Bernasconi, S.
(2006). Inflammation is a modulator of the insulin-like growth factor (IGF)/IGF-binding protein system inducing reduced bioactivity of IGFs in cystic fibrosis. Eur J Endocrinol
154: 47-52
[Abstract][Full Text]
de Jong, P A, Lindblad, A, Rubin, L, Hop, W C J, de Jongste, J C, Brink, M, Tiddens, H A W M
(2006). Progression of lung disease on computed tomography and pulmonary function tests in children and adults with cystic fibrosis. Thorax
61: 80-85
[Abstract][Full Text]
Plant, B. J., Gallagher, C. G., Bucala, R., Baugh, J. A., Chappell, S., Morgan, L., O'Connor, C. M., Morgan, K., Donnelly, S. C.
(2005). Cystic Fibrosis, Disease Severity, and a Macrophage Migration Inhibitory Factor Polymorphism. Am. J. Respir. Crit. Care Med.
172: 1412-1415
[Abstract][Full Text]
Brody, A. S., Sucharew, H., Campbell, J. D., Millard, S. P., Molina, P. L., Klein, J. S., Quan, J.
(2005). Computed Tomography Correlates with Pulmonary Exacerbations in Children with Cystic Fibrosis. Am. J. Respir. Crit. Care Med.
172: 1128-1132
[Abstract][Full Text]
Urquhart, D S, Montgomery, H, Jaffe, A
(2005). Assessment of hypoxia in children with cystic fibrosis. Arch. Dis. Child.
90: 1138-1143
[Abstract][Full Text]
Kulich, M., Rosenfeld, M., Campbell, J., Kronmal, R., Gibson, R. L., Goss, C. H., Ramsey, B.
(2005). Disease-specific Reference Equations for Lung Function in Patients with Cystic Fibrosis. Am. J. Respir. Crit. Care Med.
172: 885-891
[Abstract][Full Text]
Wagner, T., Soong, G., Sokol, S., Saiman, L., Prince, A.
(2005). Effects of Azithromycin on Clinical Isolates of Pseudomonas aeruginosa From Cystic Fibrosis Patients. Chest
128: 912-919
[Abstract][Full Text]
Clayton, A., Holland, E., Pang, L., Knox, A.
(2005). Interleukin-1{beta} Differentially Regulates {beta}2 Adrenoreceptor and Prostaglandin E2-mediated cAMP Accumulation and Chloride Efflux from Calu-3 Bronchial Epithelial Cells: ROLE OF RECEPTOR CHANGES, ADENYLYL CYCLASE, CYCLO-OXYGENASE 2, AND PROTEIN KINASE A. J. Biol. Chem.
280: 23451-23463
[Abstract][Full Text]
O'Sullivan, B. P., Linden, M. D., Frelinger, A. L. III, Barnard, M. R., Spencer-Manzon, M., Morris, J. E., Salem, R. O., Laposata, M., Michelson, A. D.
(2005). Platelet activation in cystic fibrosis. Blood
105: 4635-4641
[Abstract][Full Text]
McKeever, T. M., Lewis, S. A., Smit, H. A., Burney, P., Britton, J. R., Cassano, P. A.
(2005). The Association of Acetaminophen, Aspirin, and Ibuprofen with Respiratory Disease and Lung Function. Am. J. Respir. Crit. Care Med.
171: 966-971
[Abstract][Full Text]
Yarden, J, Radojkovic, D, De Boeck, K, Macek, M Jr, Zemkova, D, Vavrova, V, Vlietinck, R, Cassiman, J-J, Cuppens, H
(2005). Association of tumour necrosis factor alpha variants with the CF pulmonary phenotype. Thorax
60: 320-325
[Abstract][Full Text]
Bjarnsholt, T., Jensen, P. O., Burmolle, M., Hentzer, M., Haagensen, J. A. J., Hougen, H. P., Calum, H., Madsen, K. G., Moser, C., Molin, S., Hoiby, N., Givskov, M.
(2005). Pseudomonas aeruginosa tolerance to tobramycin, hydrogen peroxide and polymorphonuclear leukocytes is quorum-sensing dependent. Microbiology
151: 373-383
[Abstract][Full Text]
Voils, S. A, Evans, M. E, Lane, M. T, Schosser, R. H, Rapp, R. P
(2005). Use of Macrolides and Tetracyclines for Chronic Inflammatory Diseases. The Annals of Pharmacotherapy
39: 86-94
[Abstract][Full Text]
Tsai, W. C., Rodriguez, M. L., Young, K. S., Deng, J. C., Thannickal, V. J., Tateda, K., Hershenson, M. B., Standiford, T. J.
(2004). Azithromycin Blocks Neutrophil Recruitment in Pseudomonas Endobronchial Infection. Am. J. Respir. Crit. Care Med.
170: 1331-1339
[Abstract][Full Text]
Koehler, D. R., Downey, G. P., Sweezey, N. B., Tanswell, A. K., Hu, J.
(2004). Lung Inflammation as a Therapeutic Target in Cystic Fibrosis. Am. J. Respir. Cell Mol. Bio.
31: 377-381
[Abstract][Full Text]
Khwaja, F., Allen, J., Lynch, J., Andrews, P., Djakiew, D.
(2004). Ibuprofen Inhibits Survival of Bladder Cancer Cells by Induced Expression of the p75NTR Tumor Suppressor Protein. Cancer Res.
64: 6207-6213
[Abstract][Full Text]
Rosenbluth, D. B., Wilson, K., Ferkol, T., Schuster, D. P.
(2004). Lung Function Decline in Cystic Fibrosis Patients and Timing for Lung Transplantation Referral. Chest
126: 412-419
[Abstract][Full Text]
Paul, K., Rietschel, E., Ballmann, M., Griese, M., Worlitzsch, D., Shute, J., Chen, C., Schink, T., Doring, G., van Koningsbruggen, S., Wahn, U., Ratjen, F.
(2004). Effect of Treatment with Dornase Alpha on Airway Inflammation in Patients with Cystic Fibrosis. Am. J. Respir. Crit. Care Med.
169: 719-725
[Abstract][Full Text]
Becker, M. N., Sauer, M. S., Muhlebach, M. S., Hirsh, A. J., Wu, Q., Verghese, M. W., Randell, S. H.
(2004). Cytokine Secretion by Cystic Fibrosis Airway Epithelial Cells. Am. J. Respir. Crit. Care Med.
169: 645-653
[Abstract][Full Text]
Noone, P. G., Leigh, M. W., Sannuti, A., Minnix, S. L., Carson, J. L., Hazucha, M., Zariwala, M. A., Knowles, M. R.
(2004). Primary Ciliary Dyskinesia: Diagnostic and Phenotypic Features. Am. J. Respir. Crit. Care Med.
169: 459-467
[Abstract][Full Text]
Ordonez, C. L., Henig, N. R., Mayer-Hamblett, N., Accurso, F. J., Burns, J. L., Chmiel, J. F., Daines, C. L., Gibson, R. L., McNamara, S., Retsch-Bogart, G. Z., Zeitlin, P. L., Aitken, M. L.
(2003). Inflammatory and Microbiologic Markers in Induced Sputum after Intravenous Antibiotics in Cystic Fibrosis. Am. J. Respir. Crit. Care Med.
168: 1471-1475
[Abstract][Full Text]
Arranz, I, Martin-Suarez, A, Lanao, J M, Mora, F, Vazquez, C, Escribano, A, Juste, M, Mercader, J, Ripoll, E
(2003). Population pharmacokinetics of high dose ibuprofen in cystic fibrosis. Arch. Dis. Child.
88: 1128-1130
[Abstract][Full Text]
Gibson, R. L., Burns, J. L., Ramsey, B. W.
(2003). Pathophysiology and Management of Pulmonary Infections in Cystic Fibrosis. Am. J. Respir. Crit. Care Med.
168: 918-951
[Abstract][Full Text]
Saiman, L., Marshall, B. C., Mayer-Hamblett, N., Burns, J. L., Quittner, A. L., Cibene, D. A., Coquillette, S., Fieberg, A. Y., Accurso, F. J., Campbell, P. W. III
(2003). Azithromycin in Patients With Cystic Fibrosis Chronically Infected With Pseudomonas aeruginosa: A Randomized Controlled Trial. JAMA
290: 1749-1756
[Abstract][Full Text]
Bolton, C E, Ionescu, A A, Evans, W D, Pettit, R J, Shale, D J
(2003). Altered tissue distribution in adults with cystic fibrosis. Thorax
58: 885-889
[Abstract][Full Text]
Konstan, M. W., Krenicky, J. E., Finney, M. R., Kirchner, H. L., Hilliard, K. A., Hilliard, J. B., Davis, P. B., Hoppel, C. L.
(2003). Effect of Ibuprofen on Neutrophil Migration in Vivo in Cystic Fibrosis and Healthy Subjects. J. Pharmacol. Exp. Ther.
306: 1086-1091
[Abstract][Full Text]
Firoved, A. M., Deretic, V.
(2003). Microarray Analysis of Global Gene Expression in Mucoid Pseudomonas aeruginosa. J. Bacteriol.
185: 1071-1081
[Abstract][Full Text]
Fiel, S. B.
(2003). Early Aggressive Intervention in Cystic Fibrosis: Is It Time To Redefine Our "Best Practice" Strategies?. Chest
123: 1-3
[Full Text]
Johnson, C., Butler, S. M., Konstan, M. W., Morgan, W., Wohl, M. E. B.
(2003). Factors Influencing Outcomes in Cystic Fibrosis: A Center-Based Analysis. Chest
123: 20-27
[Abstract][Full Text]
Aldallal, N., McNaughton, E. E., Manzel, L. J., Richards, A. M., Zabner, J., Ferkol, T. W., Look, D. C.
(2002). Inflammatory Response in Airway Epithelial Cells Isolated from Patients with Cystic Fibrosis. Am. J. Respir. Crit. Care Med.
166: 1248-1256
[Abstract][Full Text]
Smith, R. S., Kelly, R., Iglewski, B. H., Phipps, R. P.
(2002). The Pseudomonas Autoinducer N-(3-Oxododecanoyl) Homoserine Lactone Induces Cyclooxygenase-2 and Prostaglandin E2 Production in Human Lung Fibroblasts: Implications for Inflammation. J. Immunol.
169: 2636-2642
[Abstract][Full Text]
Rodgers, H. C., Pang, L., Holland, E., Corbett, L., Range, S., Knox, A. J.
(2002). Bradykinin increases IL-8 generation in airway epithelial cells via COX-2-derived prostanoids. Am. J. Physiol. Lung Cell. Mol. Physiol.
283: L612-L618
[Abstract][Full Text]
Lyczak, J. B., Cannon, C. L., Pier, G. B.
(2002). Lung Infections Associated with Cystic Fibrosis. Clin. Microbiol. Rev.
15: 194-222
[Abstract][Full Text]
Peckham, D G
(2002). Macrolide antibiotics and cystic fibrosis. Thorax
57: 189-190
[Full Text]
Firoved, A. M., Boucher, J. C., Deretic, V.
(2002). Global Genomic Analysis of AlgU ({sigma}E)-Dependent Promoters (Sigmulon) in Pseudomonas aeruginosa and Implications for Inflammatory Processes in Cystic Fibrosis. J. Bacteriol.
184: 1057-1064
[Abstract][Full Text]
Cobb, B. R., Ruiz, F., King, C. M., Fortenberry, J., Greer, H., Kovacs, T., Sorscher, E. J., Clancy, J. P.
(2002). A2 adenosine receptors regulate CFTR through PKA and PLA2. Am. J. Physiol. Lung Cell. Mol. Physiol.
282: L12-L25
[Abstract][Full Text]
Sajjan, U. S., Tran, L. T., Sole, N., Rovaldi, C., Akiyama, A., Friden, P. M., Forstner, J. F., Rothstein, D. M.
(2001). P-113D, an Antimicrobial Peptide Active against Pseudomonas aeruginosa, Retains Activity in the Presence of Sputum from Cystic Fibrosis Patients. Antimicrob. Agents Chemother.
45: 3437-3444
[Abstract][Full Text]
TIRAKITSOONTORN, P., NUSSBAUM, E., MOSER, C., HILL, M., COOPER, D. M.
(2001). Fitness, Acute Exercise, and Anabolic and Catabolic Mediators in Cystic Fibrosis. Am. J. Respir. Crit. Care Med.
164: 1432-1437
[Abstract][Full Text]
Moss, R. B.
(2001). Administration of Aerosolized Antibiotics in Cystic Fibrosis Patients. Chest
120
: 107S-113S
[Abstract][Full Text]
Zhang, Y., Reenstra, W. W., Chidekel, A.
(2001). Antibacterial Activity of Apical Surface Fluid from the Human Airway Cell Line Calu-3 . Pharmacologic Alteration by Corticosteroids and beta 2-Agonists. Am. J. Respir. Cell Mol. Bio.
25: 196-202
[Abstract][Full Text]
Robinson, C. A., Kuhn, R. J.
(2001). Management of Pulmonary Disease in Patients with Cystic Fibrosis. Journal of Pharmacy Practice
14: 207-227
[Abstract]
SCHECHTER, M. S., SHELTON, B. J., MARGOLIS, P. A., FITZSIMMONS, S. C.
(2001). The Association of Socioeconomic Status with Outcomes in Cystic Fibrosis Patients in the United States. Am. J. Respir. Crit. Care Med.
163: 1331-1337
[Abstract][Full Text]
Kube, D., Sontich, U., Fletcher, D., Davis, P. B.
(2001). Proinflammatory cytokine responses to P. aeruginosa infection in human airway epithelial cell lines. Am. J. Physiol. Lung Cell. Mol. Physiol.
280: L493-L502
[Abstract][Full Text]
Robinson, P
(2001). Paediatric origins of adult lung disease {bullet} 7: Cystic fibrosis. Thorax
56: 237-241
[Full Text]
Hoiby, N.
(2001). Inflammation and infection in cystic fibrosis - hen or egg?. Eur Respir J
17: 4-5
[Full Text]
CIABATTONI, G., DAVI, G., COLLURA, M., IAPICHINO, L., PARDO, F., GANCI, A., ROMAGNOLI, R., MACLOUF, J., PATRONO, C.
(2000). In Vivo Lipid Peroxidation and Platelet Activation in Cystic Fibrosis. Am. J. Respir. Crit. Care Med.
162: 1195-1201
[Abstract][Full Text]
BUSH, A., TIDDENS, H., SILVERMAN, M.
(2000). Clinical Implications of Inflammation in Young Children. Am. J. Respir. Crit. Care Med.
162: S11-14
[Full Text]
Ben-Ari, J., Gozal, D., Dorio, R. J., Bowman, C. M., Reiff, A., Walker, S. M.
(2000). Superantigens and Cystic Fibrosis: Resistance of Presenting Cells to Dexamethasone. CVI
7: 553-556
[Abstract][Full Text]
Tsai, W. C., Strieter, R. M., Mehrad, B., Newstead, M. W., Zeng, X., Standiford, T. J.
(2000). CXC Chemokine Receptor CXCR2 Is Essential for Protective Innate Host Response in Murine Pseudomonas aeruginosa Pneumonia. Infect. Immun.
68: 4289-4296
[Abstract][Full Text]
Tewari, K. P., Malinowska, D. H., Sherry, A. M., Cuppoletti, J.
(2000). PKA and arachidonic acid activation of human recombinant ClC-2 chloride channels. Am. J. Physiol. Cell Physiol.
279: C40-C50
[Abstract][Full Text]
HØIBY, N, KOCH, C
(2000). Maintenance treatment of chronic Pseudomonas aeruginosa infection in cystic fibrosis. Thorax
55: 349-350
[Full Text]
Davis, P. B., Kercsmar, C. M.
(2000). Growth in Children with Chronic Lung Disease. NEJM
342: 887-888
[Full Text]
FERKOL, T., ECKMAN, E., SWAIDANI, S., SILSKI, C., DAVIS, P.
(2000). Transport of Bifunctional Proteins Across Respiratory Epithelial Cells via the Polymeric Immunoglobulin Receptor. Am. J. Respir. Crit. Care Med.
161: 944-951
[Abstract][Full Text]
CULLEN, A. R., CANNON, C. L., MARK, E. J., COLIN, A. A.
(2000). Mycobacterium abscessus Infection in Cystic Fibrosis . Colonization or Infection?. Am. J. Respir. Crit. Care Med.
161: 641-645
[Abstract][Full Text]
van HEECKEREN, A. M., TSCHEIKUNA, J., WALENGA, R. W., KONSTAN, M. W., DAVIS, P. B., EROKWU, B., HAXHIU, M. A., FERKOL, T. W.
(2000). Effect of Pseudomonas Infection on Weight Loss, Lung Mechanics, and Cytokines in Mice. Am. J. Respir. Crit. Care Med.
161: 271-279
[Abstract][Full Text]
CHMIEL, J. F., KONSTAN, M. W., KNESEBECK, J. E., HILLIARD, J. B., BONFIELD, T. L., DAWSON, D. V., BERGER, M.
(1999). IL-10 Attenuates Excessive Inflammation in Chronic Pseudomonas Infection in Mice. Am. J. Respir. Crit. Care Med.
160: 2040-2047
[Abstract][Full Text]
Lands, L. C., Grey, V., Smountas, A. A., Kramer, V. G., McKenna, D.
(1999). Lymphocyte Glutathione Levels in Children With Cystic Fibrosis. Chest
116: 201-205
[Abstract][Full Text]
MUHLEBACH, M. S., STEWART, P. W., LEIGH, M. W., NOAH, T. L.
(1999). Quantitation of Inflammatory Responses to Bacteria in Young Cystic Fibrosis and Control Patients. Am. J. Respir. Crit. Care Med.
160: 186-191
[Abstract][Full Text]
Oermann, C. M., Sockrider, M. M., Konstan, M. W.
(1999). The Use of Anti-inflammatory Medications in Cystic Fibrosis: Trends and Physician Attitudes. Chest
115: 1053-1058
[Abstract][Full Text]
Rubin, B. K.
(1999). Emerging Therapies for Cystic Fibrosis Lung Disease. Chest
115: 1120-1126
[Full Text]
Rutman, A., Dowling, R., Wills, P., Feldman, C., Cole, P. J., Wilson, R.
(1998). Effect of Dirithromycin on Haemophilus influenzae Infection of the Respiratory Mucosa. Antimicrob. Agents Chemother.
42: 772-778
[Abstract][Full Text]
Hennekens, C. H.
(1998). Increasing Burden of Cardiovascular Disease : Current Knowledge and Future Directions for Research on Risk Factors. Circulation
97: 1095-1102
[Full Text]
Wilson, R., Dowling, R. B
(1998). Pseudomonas aeruginosa and other related species. Thorax
53: 213-219
[Full Text]
Kovesi, T. A., Swartz, R., MacDonald, N.
(1998). Transient Renal Failure Due to Simultaneous Ibuprofen and Aminoglycoside Therapy in Children with Cystic Fibrosis. NEJM
338: 65-66
[Full Text]
Greenberger, P. A.
(1997). Immunologic Aspects of Lung Diseases and Cystic Fibrosis. JAMA
278: 1924-1930
[Abstract]
BISGAARD, H., PEDERSEN, S. S., NIELSEN, K. G., SKOV, M., LAURSEN, E. M., KRONBORG, G., REIMERT, C. M., OIBY, N. H, KOCH, C.
(1997). Controlled Trial of Inhaled Budesonide in Patients with Cystic Fibrosis and Chronic Bronchopulmonary Pseudomonas aeruginosa Infection. Am. J. Respir. Crit. Care Med.
156: 1190-1196
[Abstract][Full Text]
Previous
