FREE NEJM E-TOC    HOME   |   SUBSCRIBE   |   CURRENT ISSUE   |   PAST ISSUES   |   COLLECTIONS   |   Search Term  Advanced Search

Sign in | Get NEJM's E-Mail Table of Contents — Free | Subscribe

Previous Volume 332:884-885 March 30, 1995 Number 13 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

	Full Text Purchase this article Add to Personal Archive Add to Citation Manager Notify a Friend E-mail When Cited PubMed Citation

Genes with key roles in the development of cancer have been identified by the study of families with an inherited predisposition to particular neoplasms, such as retinoblastoma, breast and colon cancer, and now brain tumors. In each of these conditions, affected family members harbor germ-line mutations in one copy of a tumor-suppressor gene or another gene predisposing them to cancer. Subsequent somatic mutation of the second copy causes complete loss of the normal gene product and thus instigates tumor formation. Noninherited forms of the same tumor can arise by somatic inactivation of both copies of the same gene, a sporadic . . . [Full Text of this Article]

References

This article has been cited by other articles:

• Yong, W. H., Raffel, C., von Deimling, A., Louis, D. N., Rutz, H. P., Kikuchi, T. (1995). The APC Gene in Turcot's Syndrome. NEJM 333: 524-524 [Full Text]