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Correspondence
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Volume 332:892-893 March 30, 1995 Number 13
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Testing Reckless Drivers for Substance Abuse

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 by Brookoff, D.
To the Editor: The urine tests used by Brookoff et al. (Aug. 25 issue)1 detected neither cocaine nor the active component of marijuana, delta-9-tetrahydrocannabinol, but did detect their metabolites, benzoylecgonine and COOH-delta-9-tetrahydrocannabinol. Urine tests for cocaine and marijuana have been designed specifically to recognize the metabolites rather than the parent compounds, because the metabolites can be detected longer after drug use, thus increasing the sensitivity of the test for detecting any abuse. Neither metabolite is psychoactive,2,3 but both may be detected for at least one to three days after occasional use, at times when parent-drug levels and impairment have become . . . [Full Text of this Article]

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