FREE NEJM E-TOC    HOME   |   SUBSCRIBE   |   CURRENT ISSUE   |   PAST ISSUES   |   COLLECTIONS   |   Search Term  Advanced Search

Sign in | Get NEJM's E-Mail Table of Contents — Free | Subscribe

Previous Volume 332:953-954 April 6, 1995 Number 14 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

	Full Text Purchase this article Letters Add to Personal Archive Add to Citation Manager Notify a Friend E-mail When Cited Related Article PubMed Citation

Iron is essential for all organisms from bacteria to humans; but like excessive amounts of alcohol, which is so pleasant in moderation, a surfeit of iron is fatal. The lethal effects of iron overload can be immediate, as in an accidental or deliberate overdose of medicinal iron, or slow, as in congenital hemochromatosis and transfusional hemosiderosis. In the slowly developing conditions — the former due to hyperabsorption of iron in food and the latter to iatrogenic, as well as, in the case of thalassemia, hyperabsorptive factors — iron stores in the reticuloendothelial system are filled to the brim with nontoxic . . . [Full Text of this Article]

References

Related Letters:

Deferiprone in Iron Overload
Mehta J., Singhal S., Mehta B.C., Adhikari D., Hoffbrand A.V., Wonke B., Nathan D. G.
Extract | Full Text  
N Engl J Med 1995; 333:597-599, Aug 31, 1995. Correspondence

This article has been cited by other articles:

• Constantinou, G., Melides, S., Modell, B., Spino, M., Tricta, F., Nathan, D. G., Weatherall, D. J. (2003). The Olivieri Case. NEJM 348: 860-863 [Full Text]  
• Nathan, D. G., Weatherall, D. J. (2002). Academic Freedom in Clinical Research. NEJM 347: 1368-1371 [Full Text]  
• Kushner, J. P., Porter, J. P., Olivieri, N. F. (2001). Secondary Iron Overload. ASH Education Book 2001: 47-61 [Abstract] [Full Text]  
• Olivieri, N. F. (1999). The {beta}-Thalassemias. NEJM 341: 99-109 [Full Text]  
• Olivieri, N. F., Brittenham, G. M., McLaren, C. E., Templeton, D. M., Cameron, R. G., McClelland, R. A., Burt, A. D., Fleming, K. A. (1998). Long-Term Safety and Effectiveness of Iron-Chelation Therapy with Deferiprone for Thalassemia Major. NEJM 339: 417-423 [Abstract] [Full Text]  
• Mehta, J., Singhal, S., Mehta, B.C., Adhikari, D., Hoffbrand, A.V., Wonke, B., Nathan, D. G. (1995). Deferiprone in Iron Overload. NEJM 333: 597-599 [Full Text]