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Correspondence
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Volume 332:959-960 April 6, 1995 Number 14
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Severe Adverse Cutaneous Reactions to Drugs

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 by Roujeau, J. C.
To the Editor: In their excellent review of cutaneous reactions to drugs (Nov. 10 issue), Roujeau and Stern1 include vasculitis associated with lymphomas in the differential diagnosis of drug-induced vasculitis. Cutaneous vasculitis has also been associated, although infrequently, with solid tumors.2,3 Among hematologic cancers, leukemias have been associated with cutaneous vasculitis more often than lymphomas have.2 The dermatologic manifestations may antedate the discovery of the neoplasia, and pathologically, the most common manifestation is a leukocytoclastic vasculitis.


Francisco J. Fernández-Fernández, M.D.
J.A. Garrido, M.D.
Hospital A. Marcide
15405 Ferrol, Spain

References

  1. Roujeau JC, Stern RS. Severe adverse cutaneous reactions to drugs. N Engl J Med 1994;331:1272-1285. [Free Full Text]
  2. Greer JM, Longley S, Edwards NL, Elfenbein GJ, Panush RS. Vasculitis associated with malignancy: experience with 13 patients and literature review. Medicine (Baltimore) 1988;67:220-230. [Medline]
  3. Mertz LE, Conn DL. Vasculitis associated with malignancy. Curr Opin Rheumatol 1992;4:39-46. [Medline]

 
To the Editor: A mechanism by which warfarin and related compounds . . . [Full Text of this Article]

References




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