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Correspondence
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Volume 332:960-961 April 6, 1995 Number 14
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Fluoxetine

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 by Gram, L. F.
To the Editor: In his review of fluoxetine (Nov. 17 issue),1 Dr. Gram failed to mention two studies of inpatients with major depression who had improvement with fluoxetine comparable to that with desipramine2 or imipramine3 and that an analysis of results from controlled studies of more than 1500 patients with mild, moderate, or severe depression revealed no differences in rates of response or remission between patients receiving fluoxetine and those receiving tricyclic antidepressant drugs.4 With regard to drug tolerance, a meta-analysis of 42 randomized, controlled studies examined rates of drug discontinuation due to lack of efficacy or side effects in . . . [Full Text of this Article]

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